aimed toward Aygestin Generic Name: progestin (Oral route, Parenteral route, Vaginal route) Commonly used brand name(s) In the U.S. Aygestin Camila Crinone Errin First-Progesterone VGS Jolivette Megace Megace ES Next Choice Ovrette Plan B Prochieve Prometrium In Canada Alti-Mpa Megace Os Option 2 Available Dosage Forms: Tablet Suspension Capsule, Liquid Filled Gel/Jelly Cream Kit Suppository Capsule Uses For Aygestin Progestins are hormones. They are used by both men and women for different purposes. Progestins are prescribed for several reasons: To properly regulate the menstrual cycle and treat unusual stopping of the menstrual periods (amenorrhea). Progestins work by causing changes in the uterus. After the amount of progestins in the blood drops, the lining of the uterus begins to come off and vaginal bleeding occurs (menstrual period). Progestins help other hormones start and stop the menstrual cycle. . To help a pregnancy occur during egg donor or infertility procedures in women who do not produce enough progesterone. Also, progesterone is given to help maintain a pregnancy when not enough of it is made by the body. To prevent estrogen from thickening the lining of the uterus (endometrial hyperplasia) in women around menopause who are being treated with estrogen for ovarian hormone therapy (OHT). OHT is also called hormone replacement therapy (HRT) and estrogen replacement therapy (ERT). To treat pain that is related to endometriosis, a condition where the endometrial tissue which lines the uterus becomes displaced in other female organs. To treat a condition called endometriosis, to help prevent endometrial hyperplasia, or to treat unusual and heavy bleeding of the uterus (dysfunctional uterine bleeding) by starting or stopping the menstrual cycle. To help treat cancer of the breast, kidney, or uterus. Progestins help change the cancer cell's ability to react to other hormones and proteins that cause tumor growth. In this way, progestins can stop the growth of a tumor. To test the body's production of certain hormones such as estrogen. To treat loss of appetite and severe weight or muscle loss in patients with acquired immunodeficiency syndrome (AIDS) or cancer by causing certain proteins to be produced that cause increased appetite and weight gain. Progestins may also be used for other conditions as determined by your doctor. Depending on how much and which progestin you use or take, a progestin can have different effects. For instance, high doses of progesterone are necessary for some women to continue a pregnancy while other progestins in low doses can prevent a pregnancy from occurring. Other effects include causing weight gain, increasing body temperature, developing the milk-producing glands for breast-feeding, and relaxing the uterus to maintain a pregnancy. Progestins can help other hormones work properly. Progestins may help to prevent anemia (low iron in blood), too much menstrual blood loss, and cancer of the uterus. Progestins are available only with your doctor's prescription. Before Using Aygestin Allergies Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Although there is no specific information comparing use of progestins in children or teenagers with use in other age groups, this medicine is not expected to cause different side effects or problems in children or teenagers than it does in adults. Geriatric This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults. Pregnancy Progesterone, a natural hormone that the body makes during pregnancy, has not caused problems. In fact, it is sometimes used in women to treat a certain type of infertility and to aid in egg donor or infertility procedures. Other progestins have not been studied in pregnant women. Be sure to tell your doctor if you become pregnant while using any of the progestins. It is best to use some kind of birth control method while you are receiving progestins in high doses. High doses of progestins are not recommended for use during pregnancy since there have been some reports that they may cause birth defects in the genitals (sex organs) of a male fetus. Also, some of these progestins may cause male-like changes in a female fetus and female-like changes in a male fetus, but these problems usually can be reversed. Low doses of progestins, such as those doses used for contraception, have not caused major problems when used accidentally during pregnancy. Breast Feeding Although progestins pass into the breast milk, they have not been shown to cause problems in nursing babies. However, progestins may change the quality or amount (increase or decrease) of the mother's breast milk. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take. Boceprevir Dofetilide Tranexamic Acid Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Amobarbital Aprepitant Aprobarbital Bosentan Butabarbital Butalbital Carbamazepine Ceritinib Conivaptan Dabrafenib Darunavir Dexamethasone Efavirenz Eliglustat Enzalutamide Eslicarbazepine Acetate Eterobarb Etravirine Felbamate Fosphenytoin Griseofulvin Heptabarbital Hexobarbital Idelalisib Isotretinoin Lesinurad Lixisenatide Lumacaftor Mephobarbital Methohexital Mitotane Modafinil Nafcillin Netupitant Nevirapine Oxcarbazepine Pentobarbital Phenobarbital Phenytoin Pitolisant Prednisone Primidone Rifabutin Rifampin St John's Wort Sugammadex Theophylline Thiopental Tizanidine Topiramate Ulipristal Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially: Asthma or Epilepsy (or history of) or Heart or circulation problems or Kidney disease (severe) or Migraine headaches Progestins may cause fluid retention which may cause these conditions to become worse. Bleeding problems, undiagnosed, such as blood in the urine or changes in vaginal bleeding May make diagnosis of these problems more difficult. Blood clots, or history of or Breast cancer, or history of or Deep vein thrombosis (blood clot in the leg), active or history of or Heart attack, active or history of or Liver disease, including jaundice, or history of or Pulmonary embolism (clot in the lung), active or history of or Stroke , active or history of or Venous thromboembolism (clot in the veins), or history of Progestins should not be used in patients with these conditions. Breast disease (such as breast lumps or cysts), history of May make this condition worse for diseases that do not react in a positive way to progestins. Diabetes mellitus May cause an increase in your blood sugar and a change in the amount of medicine you take for diabetes; progestins in high doses are more likely to cause this problem. Memory loss (dementia) May make this condition worse. Vision changes This medicine may cause changes in vision; your medicine may need to be stopped if these conditions become worse. Proper Use of progestin This section provides information on the proper use of a number of products that contain progestin. It may not be specific to Aygestin. Please read with care. To make the use of a progestin as safe and reliable as possible, you should understand how and when to take it and what effects may be expected. Progestins usually come with patient directions. Read them carefully before taking or using this medicine. Take this medicine only as directed by your doctor. Do not take more of it and do not take it for a longer time than your doctor ordered . To do so may increase the chance of side effects. Try to take the medicine at the same time each day to reduce the possibility of side effects and to allow it to work better. Progestins are often given together with certain medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your health care professional to help you plan a way to remember to take your medicines at the right times. Dosing The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For medroxyprogesterone For oral dosage form (tablets): For controlling unusual and heavy bleeding of the uterus (dysfunctional uterine bleeding) or treating unusual stopping of menstrual periods (amenorrhea): Adults and teenagers 5 to 10 milligrams (mg) per day for five to ten days as directed by your doctor. For preparing the uterus for the menstrual period: Adults and teenagers 10 milligrams (mg) per day for five or ten days as directed by your doctor. For preventing estrogen from thickening the lining of the uterus (endometrial hyperplasia) when taking estrogen for ovarian hormone therapy in postmenopausal women: Adults When taking estrogen each day on Days 1 through 25: Oral, 5 to 10 milligrams (mg) of medroxyprogesterone per day for ten to fourteen or more days each month as directed by your doctor. Or, your doctor may want you to take 2.5 or 5 mg per day without stopping. Your doctor will help decide the number of tablets that is best for you and when to take them. For intramuscular injection dosage form: For treating cancer of the kidneys or uterus: Adults and teenagers At first, 400 to 1000 milligrams (mg) injected into a muscle as a single dose once a week. Then, your doctor may lower your dose to 400 mg or more once a month. For subcutaneous injection dosage form: For treating pain related to endometriosis: Adults and teenagers 104 milligrams (mg) injected under the skin of the anterior thigh or abdomen every three months (12 to 14 weeks) for not more than 2 years. For megestrol For oral dosage form (suspension): For treating loss of appetite (anorexia), muscles (cachexia), or weight caused by acquired immunodeficiency syndrome (AIDS): Adults and teenagers 800 milligrams (mg) a day for the first month. Then your doctor may want you to take 400 or 800 mg a day for three more months. For oral dosage form (tablets): For treating cancer of the breast: Adults and teenagers 160 milligrams (mg) a day as a single dose or in divided doses for two or more months. For treating cancer of the uterus: Adults and teenagers 40 to 320 milligrams (mg) a day for two or more months. For treating loss of appetite (anorexia), muscles (cachexia), or weight caused by cancer: Adults and teenagers 400 to 800 milligrams (mg) a day. For norethindrone For oral dosage form (tablets): For controlling unusual and heavy bleeding of the uterus (dysfunctional uterine bleeding) or treating unusual stopping of menstrual periods (amenorrhea): Adults and teenagers 2.5 to 10 milligrams (mg) a day from Day 5 through Day 25 (counting from the first day of the last menstrual cycle). Or, your doctor may want you to take the medicine only for five to ten days as directed. For treating endometriosis: Adults and teenagers At first, 5 milligrams (mg) a day for two weeks. Then, your doctor may increase your dose slowly up to 15 mg a day for six to nine months. Let your doctor know if your menstrual period starts. Your doctor may want you to take more of the medicine or may want you to stop taking the medicine for a short period of time. For progesterone For oral dosage form (capsules): For preventing estrogen from thickening the lining of the uterus (endometrial hyperplasia) when taking estrogen for ovarian hormone therapy in postmenopausal women: Adults 200 milligrams (mg) per day at bedtime for 12 continuous days per 28-day cycle of estrogen treatment each month. For treating unusual stopping of menstrual periods (amenorrhea): Adults 400 milligrams (mg) per day at bedtime for ten days. For vaginal dosage form (gel): For treating unusual stopping of menstrual periods (amenorrhea): Adults and teenagers 45 milligrams (mg) (one applicatorful of 4% gel) once every other day for up to six doses. Dose may be increased to 90 mg (one applicatorful of 8% gel) once every other day for up to six doses if needed. For use with infertility procedures: Adults and teenagers 90 milligrams (mg) (one applicatorful of 8% gel) one or two times a day. If pregnancy occurs, treatment can continue for up to ten to twelve weeks. For injection dosage form: For controlling unusual and heavy bleeding of the uterus (dysfunctional uterine bleeding) or treating unusual stopping of menstrual periods (amenorrhea): Adults and teenagers 5 to 10 milligrams (mg) a day injected into a muscle for six to ten days. Or, your doctor may want you to receive 100 or 150 mg injected into a muscle as a single dose. Sometimes your doctor may want you first to take another hormone called estrogen. If your menstrual period starts, your doctor will want you to stop taking the medicine. For vaginal dosage form (suppositories): For maintaining a pregnancy (at ovulation and at the beginning of pregnancy): Adults and teenagers 25 mg to 100 milligrams (mg) (one suppository) inserted into the vagina one or two times a day beginning near the time of ovulation. Your doctor may want you to receive the medicine for up to eleven weeks. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. For all progestins, except for progesterone capsules for postmenopausal women: If you miss a dose of this medicine, take the missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. For progesterone capsules for postmenopausal women: If you miss a dose of 200 mg of progesterone capsules at bedtime, take 100 mg in the morning then go back to your regular dosing schedule. If you take 300 mg of progesterone a day and you miss your morning and evening doses, you should not take the missed dose. Return to your regular dosing schedule. Storage Keep out of the reach of children. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Do not keep outdated medicine or medicine no longer needed. Precautions While Using Aygestin It is very important that your doctor check your progress at regular visits . This will allow for your dosage to be adjusted and for any unwanted effects to be detected. These visits will usually be every 6 to 12 months, but some doctors require them more often. The Prometrium capsules contain peanut oil. If you have an allergy to peanuts, make sure your doctor knows this before you take this brand of progestin. Progestins may cause some people to become dizzy. For oral or vaginal progesterone, dizziness or drowsiness may occur 1 to 4 hours after taking or using it. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert. Unusual or unexpected vaginal bleeding of various amounts may occur between your regular menstrual periods during the first 3 months of use. This is sometimes called spotting when slight, or breakthrough menstrual bleeding when heavier. If this should occur, continue on your regular dosing schedule. Check with your doctor : If unusual or unexpected vaginal bleeding continues for an unusually long time. If your menstrual period has not started within 45 days of your last period. Missed menstrual periods may occur. If you suspect a pregnancy, you should stop taking this medicine immediately and call your doctor . Your doctor will let you know if you should continue taking the progestin. If you are scheduled for any laboratory tests, tell your health care professional that you are taking a progestin. Progestins can change certain test results. In some patients, tenderness, swelling, or bleeding of the gums may occur. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this. See your dentist regularly to have your teeth cleaned. Check with your medical doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums. You will need to use a birth control method while taking progestins for noncontraceptive use if you are fertile and sexually active . If you are using vaginal progesterone, avoid using other vaginal products for 6 hours before and for 6 hours after inserting the vaginal dose of progesterone. Since it is possible that certain doses of progestins may cause temporary thinning of the bones by changing your hormone balance, it is important that your doctor know if you have an increased risk of osteoporosis. Some things that can increase your risk for having osteoporosis include cigarette smoking, abusing alcohol, taking or drinking large amounts of caffeine, and having a family history of osteoporosis or easily broken bones. Some medicines, such as glucocorticoids (cortisone-like medicines) or anticonvulsants (seizure medicine), can also cause thinning of the bones. However, it is thought that progestins can help protect against osteoporosis in postmenopausal women. Aygestin Side Effects Along with their needed effects, progestins used in high doses sometimes cause some unwanted effects such as blood clots, heart attacks, and strokes, or problems of the liver and eyes. Although these effects are rare, some of them can be very serious and cause death. It is not clear if these problems are due to the progestin. They may be caused by the disease or condition for which progestins are being used. The following side effects may be caused by blood clots. Although not all of these side effects may occur, if they do occur they need immediate medical attention. Get emergency help immediately if any of the following side effects occur: Rare Symptoms of blood clotting problems, usually severe or sudden, such as: headache or migraine loss of or change in speech, coordination, or vision numbness of or pain in chest, arm, or leg unexplained shortness of breath Check with your doctor as soon as possible if any of the following side effects occur: More common Changes in vaginal bleeding (increased amounts of menstrual bleeding occurring at regular monthly periods, lighter vaginal bleeding between menstrual periods, heavier vaginal bleeding between regular monthly periods, or stopping of menstrual periods) symptoms of blood sugar problems (dry mouth, frequent urination, loss of appetite, or unusual thirst) Less common Mental depression skin rash unexpected or increased flow of breast milk Rare For megestrol During chronic treatment Backache dizziness filling or rounding out of the face irritability mental depression nausea or vomiting unusual decrease in sexual desire or ability in men unusual tiredness or weakness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal pain or cramping bloating or swelling of ankles or feet blood pressure increase (mild) dizziness drowsiness (progesterone only) headache (mild) mood changes nervousness pain or irritation at place of injection site swelling of face, ankles, or feet unusual or rapid weight gain Less common Acne breast pain or tenderness brown spots on exposed skin, possibly long-lasting hot flashes loss or gain of body, facial, or scalp hair loss of sexual desire trouble in sleeping Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. All of the progestins are similar, so any of the above side effects may occur with any of these medicines. After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice the following side effect: For megestrol Dizziness nausea or vomiting unusual tiredness or weakness Delayed return to fertility stopping of menstrual periods unusual menstrual bleeding (continuing) Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Print this page The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. 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