wakened azacitidine (Injection route) ay-za-SYE-ti-deen Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Vidaza Available Dosage Forms: Powder for Suspension Therapeutic Class: Antineoplastic Agent Slideshow Sexual Health Q+A: Your Questions Answered Uses For azacitidine Azacitidine injection is used to treat patients with French-American-British (FAB) myelodysplastic syndrome subtypes, including refractory anemia or chronic leukemia. Azacitidine belongs to the group of medicines called metabolites. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by azacitidine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Some effects may not occur for months or years after the medicine is used. azacitidine is to be given only by or under the direct supervision of your doctor. Before Using azacitidine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For azacitidine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to azacitidine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of azacitidine injection in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of azacitidine injection in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution in patients receiving azacitidine injection. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of azacitidine. Make sure you tell your doctor if you have any other medical problems, especially: Allergy to mannitol or Cancerous liver tumors Should not be used in patients with these conditions. Anemia or Liver disease or Neutropenia (low white blood cells) or Thrombocytopenia (low number of platelets) Use with caution. May make these conditions worse. Kidney disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of azacitidine A nurse or other trained health professional will give you azacitidine. You may also be taught how to give your medicine at home. azacitidine is given as a shot under your skin or into a vein. azacitidine is given once a day, for 7 days (1 treatment cycle). Then, you may receive azacitidine every 4 weeks. You may also receive medicines to help prevent nausea and vomiting. Cancer medicines can cause nausea or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects. Missed Dose azacitidine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions. Precautions While Using azacitidine It is very important that your doctor check your progress at regular visits to make sure that azacitidine is working properly. Blood tests will be needed to check for unwanted effects. Your unborn baby could be harmed if you use azacitidine while you are pregnant. Women receiving azacitidine injection should use an effective form of birth control to keep from getting pregnant There is also a potential for azacitidine to cause birth defects if the father is using it when his sexual partner becomes pregnant. If a pregnancy occurs while you are receiving azacitidine, tell your doctor right away. Azacitidine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding: If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Check with your doctor immediately if you notice any unusual bleeding or bruising black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur. azacitidine may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness. azacitidine Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Black, tarry stools bladder pain bleeding gums blood in the urine or stools cloudy urine body aches or pain burning or stinging of the skin chest pain chills congestion cough difficult breathing difficulty swallowing dizziness ear congestion fast heartbeat fever frequent urge to urinate headache hives, itching, or skin rash hoarseness loss of voice lower back or side pain muscle aches nasal congestion nausea pain or tenderness around the eyes and cheekbones painful cold sores or blisters on the lips, nose, eyes, or genitals painful or difficult urination pain, redness, swelling, tenderness, warmth on the skin pale skin pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips or tongue rapid heartbeat runny nose sneezing sore throat sores, ulcers, or white spots on lips or in mouth stuffy nose swollen glands tender, swollen glands in the neck tightness in the chest troubled breathing with exertion unusual bleeding or bruising unusual tiredness or weakness voice changes vomiting Less common Change in consciousness convulsions decreased urine drowsiness dry mouth increased thirst irregular heartbeat loss of appetite mood changes muscle pain or cramps numbness or tingling in the hands, feet, or lips loss of consciousness Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Diarrhea nausea vomiting Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach appetite decreased belching bleeding after defecation bloody nose blurred vision bruise bumps on the skin burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings burning while urinating diarrhea difficulty having a bowel movement (stool) difficulty with moving discouragement dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position dry skin fainting fear feeling of discomfort or illness feeling of sluggishness feeling sad or empty feeling unusually cold flushing full or bloated feeling or pressure in the stomach heartburn heart murmur indigestion inflamed tissue from infection at the injection site injection site bruising irritability itching at injection site joint pain lack of appetite large, flat, blue or purplish patches in the skin loss of interest or pleasure mouth hemorrhage muscle stiffness nervousness night sweats pain in the joints postnasal drip post procedural hemorrhage redness of the skin shivering small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope small lumps under the skin small red or purple spots in the mouth soreness or discomfort to touch or pressure on the stomach stomach discomfort upset or pain sweating swelling of abdominal or stomach area swelling of the hands, ankles, feet, or lower legs swelling or inflammation of the mouth swelling with pits or depressions visible on the skin swollen joints tongue ulceration trouble concentrating trouble sleeping uncomfortable swelling around the anus unusual drowsiness unusually warm skin upper abdominal or stomach pain weight loss Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about azacitidine Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 13 Reviews Add your own review/rating Drug class: miscellaneous antineoplastics Consumer resources Azacitidine Other brands: Vidaza Professional resources Azacitidine (AHFS Monograph) Azacitidine Injection (FDA) AzaCITIDine (Wolters Kluwer) Related treatment guides Myelodysplastic Syndrome} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Dr. Reddy's Laboratories, Inc. Sandoz Inc. Wockhardt USA LLC Drug Class Miscellaneous antineoplastics Related Drugs Myelodysplastic Syndrome Vidaza , decitabine , azacitidine , Dacogen , More... Azacitidine Rating 13 User Reviews 6.1 /10 13 User Reviews 6.1 Rate it! Related Questions & Answers How can we buy this vidaza azacitidine? 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