right away Signifor LAR Generic Name: pasireotide (PAS i REE oh tide) Brand Name: Signifor, Signifor LAR Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons What is Signifor LAR (pasireotide)? Pasireotide is a man-made protein that is similar to a hormone in the body called somatostatin. Pasireotide lowers certain hormone substances produced in the body. Pasireotide is used to treat Cushing's disease or acromegaly (endocrine disorders). Pasireotide is usually given after surgery or other treatments have been tried without success. Pasireotide may also be used for purposes not listed in this medication guide. Slideshow FDA-Approved Weight Loss Drugs: Can They Help You? What is the most important information I should know about Signifor LAR (pasireotide)? Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. What should I discuss with my healthcare provider before using Signifor LAR (pasireotide)? You should not use pasireotide if you are allergic to it. Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using pasireotide. To make sure pasireotide is safe for you, tell your doctor if you have: diabetes; liver disease; a heart rhythm disorder; personal or family history of long QT syndrome; gallbladder disease; or a history of an electrolyte imbalance (such as low levels of potassium or magnesium in your blood). It is not known whether pasireotide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. It is not known whether pasireotide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How is Signifor LAR (pasireotide)given? Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using pasireotide. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Pasireotide is injected under the skin, usually twice per day. You may be shown how to use injections at home. Do not self inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes. Signifor LAR is injected into a muscle once every 4 weeks. A healthcare provider will give you this type of pasireotide injection. Your care provider will show you the best places on your body to inject pasireotide under the skin. Use a different place each time you give an injection. Do not inject into the same place two times in a row. Avoid injecting pasireotide into skin that is red or irritated. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine. Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets. Each Signifor single-use ampule is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose. While using pasireotide, you may need frequent blood tests. Check your blood sugar carefully if you are diabetic. Store Signifor at room temperature, away from moisture, heat, and light. If you store Signifor LAR at home, keep it in the original carton in the refrigerator. Do not freeze. Signifor LAR should be at room temperature when you inject it. Take the medicine out of the refrigerator at least 30 minutes before your injection is to be given. Once the medicine reaches room temperature, you must use it within 24 hours. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. What happens if I miss a dose? Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using Signifor LAR (pasireotide)? Do not inject this medicine into skin that is red or irritated. Signifor LAR (pasireotide) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: slow heart rate, feeling like you might pass out; low cortisol levels--joint or muscle pain, muscle weakness, loss of appetite, tired feeling, weight loss, craving salty foods, mood changes, irritability; high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or gallbladder problem--chalky-colored stools, stomach pain just after eating a meal, nausea, heartburn, bloating, and severe upper stomach pain that may spread to your back. Common side effects may include: feeling weak or tired; nausea, stomach pain, diarrhea; headache; swelling, bloated feeling; cold symptoms such as stuffy nose, sneezing, sore throat; hair loss; or pain, redness, itching, bruising or bleeding where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect Signifor LAR (pasireotide)? Many drugs can interact with pasireotide. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with pasireotide, especially: bromocriptine; cyclosporine; anagrelide; droperidol; methadone; ondansetron; an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine; cancer medicine--arsenic trioxide, vandetanib; an antidepressant--citalopram, escitalopram; anti-malaria medication--chloroquine, halofantrine; heart or blood pressure medicine--amlodipine, atenolol, carvedilol, labetalol, metoprolol, nebivolol, sotalol, verapamil, and others; heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; medicines to control electrolyte disorders--calcium gluconate, sodium polystyrene sulfonate, tolvaptan; or medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, pimozide, thioridazine. This list is not complete and many other drugs can interact with pasireotide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. Next Side Effects Print this page Add to My Med List More about Signifor LAR (pasireotide) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: somatostatin and somatostatin analogs Consumer resources Signifor LAR (Advanced Reading) Other brands: Signifor Professional resources Signifor LAR Injection (FDA) Pasireotide (AHFS Monograph) Related treatment guides Acromegaly Where can I get more information? Your pharmacist can provide more information about pasireotide. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 1.02. Date modified: December 03, 2017 Last reviewed: January 14, 2015} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Manufacturer Novartis Pharmaceuticals Corporation Drug Class Somatostatin and somatostatin analogs Related Drugs Acromegaly octreotide , Sandostatin , bromocriptine , Parlodel , lanreotide , Somatuline Depot , Sandostatin LAR Depot , Somavert , pegvisomant , pasireotide , More... Signifor LAR Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the Signifor LAR support group to connect with others who have similar interests.} } is generally
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