much more likely Aptivus (Oral) Generic Name: tipranavir (Oral route) tye-PRAN-a-vir Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Oral route(Capsule;Solution) Clinical hepatitis and hepatic decompensation, including some fatalities, have been reported. Extra vigilance is warranted in patients with chronic hepatitis B or hepatitis C co-infection. Fatal and nonfatal intracranial hemorrhage have also been reported . Commonly used brand name(s) In the U.S. Aptivus Available Dosage Forms: Solution Capsule, Liquid Filled Therapeutic Class: Antiviral Pharmacologic Class: Protease Inhibitor Slideshow Save Your Blushes - The FAQ's On STDs Uses For Aptivus Tipranavir is used in combination with ritonavir (Norvir ) to treat an infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). This medicine is usually given to patients who have received HIV treatment in the past. Tipranavir will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems usually related to AIDS or HIV disease from occurring. Tipranavir will not keep you from spreading HIV to other people. People who receive this medicine may continue to have the problems usually related to AIDS or HIV disease. This medicine is available only with your doctor's prescription. Before Using Aptivus In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of tipranavir in children younger than 2 years of age. Safety and efficacy have not been established. Geriatric Although appropriate studies on the relationship of age to the effects of tipranavir have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving tipranavir. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Alfuzosin Amiodarone Astemizole Bepridil Cisapride Colchicine Dihydroergotamine Ergonovine Ergotamine Flecainide Grazoprevir Isavuconazonium Sulfate Lovastatin Lurasidone Methylergonovine Midazolam Naloxegol Pazopanib Pimozide Primidone Propafenone Quinidine Rifampin Romidepsin Sildenafil Simvastatin St John's Wort Terfenadine Tolvaptan Triazolam Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Ado-Trastuzumab Emtansine Afatinib Amprenavir Apixaban Artemether Atazanavir Atorvastatin Bedaquiline Boceprevir Bosentan Brentuximab Vedotin Cabazitaxel Carbamazepine Ceritinib Cilostazol Cobicistat Conivaptan Cyclophosphamide Dabigatran Etexilate Darunavir Delamanid Dolutegravir Doxorubicin Doxorubicin Hydrochloride Liposome Eluxadoline Etravirine Fluticasone Fosamprenavir Garlic Idelalisib Ifosfamide Indinavir Irinotecan Irinotecan Liposome Ketoconazole Ledipasvir Levomilnacipran Linagliptin Lopinavir Lumacaftor Lumefantrine Macitentan Methadone Nelfinavir Olaparib Orlistat Palbociclib Panobinostat Piperaquine Pixantrone Ponatinib Retapamulin Rifabutin Rifapentine Rilpivirine Ruxolitinib Salmeterol Saquinavir Simeprevir Sofosbuvir Tadalafil Telaprevir Tenofovir Alafenamide Velpatasvir Vilanterol Vilazodone Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abacavir Aluminum Carbonate, Basic Aluminum Hydroxide Aluminum Phosphate Bupropion Calcium Carbonate Clarithromycin Conjugated Estrogens Dihydroxyaluminum Aminoacetate Dihydroxyaluminum Sodium Carbonate Enfuvirtide Esterified Estrogens Estradiol Estriol Estrone Estropipate Ethinyl Estradiol Fluconazole Magaldrate Magnesium Carbonate Magnesium Hydroxide Magnesium Oxide Magnesium Trisilicate Omeprazole Rosuvastatin Tenofovir Disoproxil Fumarate Trazodone Zidovudine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Bleeding problems (eg, hemophilia) Use with caution. May increase the chance of bleeding. Diabetes mellitus or Hyperglycemia (high blood sugar) May increase the amount of sugar in your blood. Hyperlipidemia (high cholesterol or fats in the blood) or Liver problems (including hepatitis B or C) Use with caution. May make these conditions worse. . Liver disease, moderate or severe Should not be used in patients with this condition. Sulfa allergy, known or suspected Use with caution. May cause side effects to be worse. Proper Use of Aptivus Take this medicine exactly as directed by your doctor . Do not change your dose or stop using this medicine without checking first with your doctor. When your supply of this medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of this medicine. This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. Tipranavir is always taken with ritonavir (Norvir ). Take these two medicines at the same time, unless your doctor tells you otherwise. If you are using this medicine with ritonavir capsules or oral liquid , you may take it with or without food. However, you should take this medicine with food if you are using it with ritonavir tablets . Swallow the capsule whole. Do not break, crush, or chew it. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For treatment of HIV infection: For oral dosage forms (capsules or oral solution): Adults 500 milligrams (mg) (two capsules or 5 milliliters (mL)) of tipranavir and 200 mg of ritonavir (Norvir ) two times a day. Children 2 to 18 years of age Dose is based on body weight or body size and must be determined by your doctor. The dose is usually 14 milligrams (mg) per kilogram (kg) of body weight of tipranavir plus 6 mg per kg of body weight of ritonavir (Norvir ), or 375 mg/m(2) of body size of tipranavir plus 150 mg/m(2) of body size of ritonavir two times a day. Your doctor may adjust your dose if needed. However, the dose should not be more than the recommended adult dose. Children younger than 2 years of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the capsules in the refrigerator until you are ready to open the bottle. Once you have opened the medicine bottle, you may store it at room temperature, away from heat, light, or moisture. The medicine is good for up to 60 days after you open the bottle. Throw away any unused capsules after 60 days and get a new bottle of medicine. . Store the oral liquid at room temperature. Do not refrigerate or freeze it. The liquid must be used within 60 days after you open the bottle. Precautions While Using Aptivus It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. You should not use tipranavir together with alfuzosin (Uroxatral ), amiodarone (Cordarone , Pacenone ), bepridil (Vascor ), cisapride (Propulsid ), ergot medicines (eg, dihydroergotamine, ergonovine, ergotamine, methylergonovine, Cafergot , Methergine , Migranal ), flecainide (Tambocor ), lovastatin (Altocor , Mevacor ), oral lurasidone (Latuda ), midazolam (Versed ) pimozide (Orap ), propafenone (Rythmol ), quinidine (Cardioquin , Quinaglute Dura ), rifampin (Rifadin , Rimactane ), sildenafil (Revatio ), simvastatin (Simcor , Vytorin , Zocor ), or triazolam (Halcion ). Using these medicines together with tipranavir may increase your chance of having serious medical problems. This medicine may decrease the effects of some oral contraceptives (birth control pills). To keep from getting pregnant, use an additional form of birth control with your pills. Other forms include condoms, a diaphragm, or contraceptive foam or jelly. This medicine may cause intracranial hemorrhage (bleeding in the brain). Make sure your doctor knows if you or your child have a bleeding disorder, or any medical condition that increases your chance of bleeding. Call your doctor right away if you have any unusual or unexplained bleeding. Check with your doctor right away if you or your child have pain in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. When you start taking HIV medicines, your immune system may get stronger. If you have certain infections that are hidden in your body, such as pneumonia or tuberculosis, you or your child may notice new symptoms when your body tries to fight them. If this occurs, tell your doctor right away. This medicine will not keep you from giving HIV to your partner during sex. Make sure you understand and practice safe sex, even if your partner also has HIV. Do not share needles with anyone. Serious skin reactions can occur with this medicine. Check with your doctor right away if you or your child have more than one of the following symptoms while using this medicine: blistering, peeling, or loosening of the skin, fever or chills, itching, joint or muscle pain, severe rash, red skin lesions, sunburn, throat tightness, or sores, ulcers, or white spots in the mouth or on the lips. This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Wear protective clothing and hats. Avoid sunlamps and tanning beds. This medicine may cause you to have excess body fat. Tell your doctor if you or your child notice changes in your body shape, such as an increased amount of fat in the upper back and neck, or around the chest and stomach area, or a loss of fat from the legs, arms, and face. Aptivus Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Bleeding gums confusion cough producing mucus coughing up blood difficulty with breathing or swallowing dizziness fever general feeling of tiredness or weakness headache increased menstrual flow or vaginal bleeding loss of appetite nausea or vomiting nosebleeds paralysis prolonged bleeding from cuts red or black, tarry, or light-colored stools red or dark brown urine sudden severe weakness tightness in the chest unusual bleeding upper right abdominal or stomach pain yellow eyes and skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea Less common Abdominal or stomach pain cough discouragement fat redistribution feeling sad or empty irritability lack of appetite lack or loss of strength loss of interest or pleasure rash trouble concentrating trouble sleeping Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about Aptivus (tipranavir) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: protease inhibitors Consumer resources Aptivus Aptivus (Tipranavir Capsules) Aptivus (Tipranavir Oral Solution) Professional resources Aptivus (AHFS Monograph) Aptivus (FDA) Related treatment guides HIV Infection} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug 10 + years Approval History FDA approved 2005 Manufacturer Boehringer Ingelheim Pharmaceuticals, Inc. Drug Class Protease inhibitors Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , abacavir , tenofovir , Reyataz , Epzicom , ritonavir , Complera , emtricitabine , darunavir , Kaletra , Intelence , Sustiva , Epivir , efavirenz , nevirapine , atazanavir , raltegravir , Selzentry , More... Aptivus Rating No Reviews - Be the first! 7.0 /10 No Reviews - Be the first! 7.0 Rate it! Aptivus Images Aptivus 250 mg (TPV 250 ) View larger images Help and Support Looking for answers? Ask a question or go join the Aptivus support group to connect with others who have similar interests.} } mothers and fathers
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