terrific Famotidine use while Breastfeeding Drugs containing Famotidine: Pepcid, Duexis, Pepcid AC, Pepcid Complete, Heartburn Relief, Acid Control, Pepcid AC Maximum Strength Tablets, Fluxid, Pepcid Oral Suspension, Acid Reducer-Famotidine, Show all 26 Acid Controller Maximum Strength, Pepcid AC Maximum Strength, Heartburn Relief Maximum Strength, Acid Reducer Maximum Strength, Acid Controller Complete, Dual-Action Acid Controller Complete, Acid Controller Complete Dual Action, Dual Action Complete, Acid Reducer + Antacid Dual Action, Tums Dual Action, Acid Reducer Original Strength, Acid Controller Original Strength, Pepcid RPD, Mylanta AR, Pepcid AC Chewable Tablets, Complete Acid Reducer plus Antacid Overview Side Effects Dosage Professional Tips More Interactions Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Compare Alternatives Pricing & Coupons Famotidine Levels and Effects while Breastfeeding Summary of Use during Lactation Famotidine is used in newborn infants in higher dosages than are transmitted in breastmilk.[1] Famotidine would not be expected to cause any adverse effects in breastfed infants. No special precautions are required. Drug Levels Maternal Levels. Eight women who had "recently given birth" (not defined, but apparently within a few days postpartum) were given famotidine 40 mg orally. An average peak breastmilk level of 72 mcg/L occurred 6 hours after the dose.[2] Using the peak milk level data from this study, an exclusively breastfed infant would receive an estimated maximum of 0.01 mg/kg daily with this maternal dosage regimen or less than 2% of the maternal weight-adjusted dosage. Seven women were given oral famotidine 40 mg daily in 2 or 4 divided doses for 3 days at 12 to 16 weeks postpartum. Average concentrations of famotidine in breastmilk were 53 and 55 mcg/L at 3 and 6 hours after a dose, respectively.[3] Infant Levels. Relevant published information was not found as of the revision date. Effects in Breastfed Infants Relevant published information was not found as of the revision date. Effects on Lactation and Breastmilk Histamine H2-receptor blockade is known to stimulate prolactin secretion.[4] Oral famotidine usually does not affect serum prolactin levels, but rare cases of hyperprolactinemia and galactorrhea have been reported.[5][6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed. Alternate Drugs to Consider Cimetidine , Nizatidine , Omeprazole , Pantoprazole , Ranitidine , Sucralfate References 1. Orenstein SR, Shalaby TM, Devandry SN et al. Famotidine for infant gastro-oesophageal reflux: A multi-centre, randomized, placebo-controlled, withdrawal trial. Aliment Pharmacol Ther. 2003;17(9):1097-107. PMID: 12752346 2. Courtney TP, Shaw RW, Cedar E et al. Excretion of famotidine in breast milk. Br J Clin Pharmacol. 1988;26:639P. Abstract. PMC: PMC1386642 3. Wang X, Zhan Y, Hankins GD et al. Pharmacokinetics of famotidine in pregnant women. Am J Obstet Gynecol. 2011;204:S72-3. Abstract. 4. Knigge UP. Histaminergic regulation of prolactin secretion. Dan Med Bull. 1990;37:109-24. PMID: 2188799 5. Delpre G, Lapidot M, Lipchitz A et al. Hyperprolactinaemia during famotidine therapy. Lancet. 1993;342:868. Letter. PMID: 8104296 6. Guven K, Kelestimur F. Hyperprolactinemia and galactorrhea with standard-dose famotidine therapy. Ann Pharmacother. 1995;29:788. Letter. PMID: 8520102 Famotidine Identification Substance Name Famotidine CAS Registry Number 76824-35-6 Drug Class Anti-Ulcer Agents Histamine H2 Antagonists Administrative Information LactMed Record Number 398 Last Revision Date 20170411 Disclaimer Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site. Print this page Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy. More about famotidine Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Español 21 Reviews Add your own review/rating Drug class: H2 antagonists Consumer resources Famotidine Famotidine Chewable Tablets Famotidine Injection Solution Famotidine Tablets Famotidine Oral Suspension Famotidine (Advanced Reading) Other brands: Pepcid , Pepcid AC , Heartburn Relief , Pepcid Oral Suspension , ... +2 more Professional resources Famotidine (AHFS Monograph) ... +4 more Related treatment guides GERD Urticaria Allergic Urticaria Indigestion ... +9 more Drug Status Rx OTC Availability Rx and/or OTC B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Famotidine Rating 21 User Reviews 7.1 /10 21 User Reviews 7.1 Rate it! Drug Class H2 antagonists a realistic
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