conflict empagliflozin and metformin Generic Name: empagliflozin and metformin (EM pa gli FLOE zin and met FOR min) Brand Name: Synjardy, Synjardy XR Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A What is empagliflozin and metformin? Empagliflozin and metformin are oral diabetes medicines that help control blood sugar levels. Empagliflozin works by helping the kidneys get rid of glucose from your bloodstream. Metformin lowers glucose production in the liver and also causes your intestines to absorb less glucose. Empagliflozin and metformin is a combination medicine used together with diet and exercise to improve blood sugar control in adults with diabetes mellitus. Empagliflozin and metformin is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease. This medicine is not for treating type 1 diabetes. Empagliflozin and metformin may also be used for purposes not listed in this medication guide. Slideshow Always Hungry? You Just Might Have One Of These Conditions What is the most important information I should know about empagliflozin and metformin? You should not use this medicine if you have moderate to severe kidney disease, if you are on dialysis, or if you have metabolic acidosis. Empagliflozin and metformin is not for treating type 1 diabetes. If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking empagliflozin and metformin. This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. What should I discuss with my healthcare provider before taking empagliflozin and metformin? You should not use this medicine if you are allergic to empagliflozin (Jardiance, Glyxambi) or metformin (Glucophage, Actoplus Met, Avandamet, Fortamet, Glucovance, Janumet, Jentadueto, Kazano, Kombiglyze, Metaglip, PrandiMet, Riomet), or if you have: moderate to severe kidney disease (or if you are on dialysis); or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking empagliflozin and metformin. Some people taking metformin develop a serious condition called lactic acidosis. This may be more likely if you have liver or kidney disease, congestive heart failure, surgery, a heart attack or stroke, a severe infection, if you are 65 or older, if you are dehydrated, or if you drink a lot of alcohol. Talk with your doctor about your risk. To make sure empagliflozin and metformin is safe for you, tell your doctor if you have ever had: liver or kidney disease; low blood pressure; a bladder infection or urination problems; heart problems; problems with your pancreas, including surgery; or if you are on a low-salt diet. It is not known whether empagliflozin and metformin will harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant while taking this medicine. It is not known whether this medicine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking empagliflozin and metformin. Empagliflozin and metformin is not approved for use by anyone younger than 18 years old. How should I take empagliflozin and metformin? Your doctor may perform kidney function tests before you start taking empagliflozin and metformin. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take this medicine with food to prevent upset stomach. Do not crush, chew, or break an extended-release tablet. Swallow it whole. If you need to fast (stop eating) before a surgery, tell the surgeon ahead of time that you take empagliflozin and metformin. You may need to stop using the medicine for a short time. Call your doctor if you are sick with vomiting or diarrhea, if you consume less food or fluid than usual, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine. Your blood sugar will need to be checked often, and you may also need to test the level of ketones your urine. Empagliflozin can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have ketones in the urine. Empagliflozin and metformin can cause positive results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using this medicine. Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda. Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency. Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness. Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule. Empagliflozin and metformin is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor's instructions very closely. Your doctor may have you take extra vitamin B12 while you are taking empagliflozin and metformin. Take only the amount of vitamin B12 that your doctor has prescribed. Store at room temperature, away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of metformin may cause lactic acidosis. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. What should I avoid while taking empagliflozin and metformin? Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis while taking this medicine. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Empagliflozin and metformin side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Early symptoms of lactic acidosis may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Call your doctor at once if you have: little or no urination; dehydration symptoms--dizziness, weakness, feeling light-headed (like you might pass out); ketoacidosis (too much acid in the blood)--nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; signs of a bladder infection--pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back; or signs of a genital infection (penis or vagina)--pain, burning, itching, rash, redness, odor, or discharge. Side effects may be more likely to occur in older adults. Common side effects may include: headache; stomach pain, gas, indigestion, nausea, vomiting, diarrhea; weakness; or runny nose, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Empagliflozin and metformin dosing information Usual Adult Dose for Diabetes Type 2: Individualize dosage based on patient's current regimen Empagliflozin/metformin IMMEDIATE-RELEASE: Patients on metformin: -Initial dose: empagliflozin 10 mg plus similar total daily dose of metformin divided orally twice a day Patients on empagliflozin: -Initial dose: empagliflozin at the same total daily dose plus metformin 1000 mg/day divided orally twice a day Patients on empagliflozin and metformin: -Initial dose: same total daily dose of each component (or nearest appropriate dose of metformin) divided orally twice a day Empagliflozin/metformin EXTENDED-RELEASE: Patients on metformin: -Initial dose: empagliflozin 10 mg plus similar total daily dose of metformin orally once a day Patients on empagliflozin: -Initial dose: empagliflozin at the same total daily dose plus metformin 1000 mg/day orally once a day Patients on empagliflozin and metformin: -Initial dose: same total daily dose of each component (or nearest appropriate dose of metformin) orally once a day Maintenance: Adjust dose based on efficacy and tolerability; a gradual dose escalation of metformin will help to reduce gastrointestinal side effects. Maximum dose: empagliflozin: 25 mg/day; metformin: 2000 mg/day Comments: -When used in combination with insulin or an insulin secretagogue, a lower dose of insulin or insulin secretagogue should be considered to reduce the risk of hypoglycemia. -Empagliflozin has been shown to reduce the risk of cardiovascular (CV) death in adults with type 2 diabetes mellitus and established CV disease, however, the effectiveness of this combination drug in reducing the risk of CV death has not been established. -Correct volume depletion prior to beginning this drug. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both empagliflozin and metformin is appropriate. What other drugs will affect empagliflozin and metformin? Tell your doctor about all your current medicines and any you start or stop using, especially: blood pressure medicine; a diuretic or "water pill"; insulin or other oral diabetes medications; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may interact with empagliflozin and metformin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Next Side Effects Print this page Add to My Med List More about empagliflozin/metformin Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 3 Reviews Add your own review/rating Drug class: antidiabetic combinations Consumer resources Empagliflozin and Metformin Extended-Release Tablets Empagliflozin and Metformin Tablets Empagliflozin and metformin (Advanced Reading) Other brands: Synjardy , Synjardy XR Professional resources Empagliflozin and Metformin (Wolters Kluwer) Related treatment guides Diabetes, Type 2 Where can I get more information? Your pharmacist can provide more information about empagliflozin and metformin. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 1.05. Date modified: December 03, 2017 Last reviewed: July 27, 2017} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antidiabetic combinations Related Drugs Diabetes, Type 2 metformin , insulin aspart , glipizide , glimepiride , Januvia , pioglitazone , Victoza , Actos , Tradjenta , Glucophage , glyburide , Janumet , Invokana , Amaryl , Welchol , Onglyza , sitagliptin , Trulicity , Jardiance , Lantus , Farxiga , Levemir , Tresiba , Glucotrol , Bydureon , More... Empagliflozin / metformin Rating 3 User Reviews 10 /10 3 User Reviews 10 Rate it! Help and Support Looking for answers? Ask a question or go join the empagliflozin / metformin support group to connect with others who have similar interests.} } worrying
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