get rid of Topcare 8 Hour Pain Relief Side Effects Generic Name: acetaminophen Side Effects Dosage Professional Interactions Pregnancy More Breastfeeding Warnings User Reviews Note: This document contains side effect information about acetaminophen. Some of the dosage forms listed on this page may not apply to the brand name Topcare 8 Hour Pain Relief. For the Consumer Applies to acetaminophen: capsule, capsule liquid filled, elixir, liquid, powder, powder for solution, solution, suppository, suspension, syrup, tablet, tablet chewable, tablet disintegrating, tablet effervescent, tablet extended release Other dosage forms: intravenous solution Along with its needed effects, acetaminophen (the active ingredient contained in Topcare 8 Hour Pain Relief) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking acetaminophen: Rare Bloody or black, tarry stools bloody or cloudy urine fever with or without chills (not present before treatment and not caused by the condition being treated) pain in the lower back and/or side (severe and/or sharp) pinpoint red spots on the skin skin rash, hives, or itching sore throat (not present before treatment and not caused by the condition being treated) sores, ulcers, or white spots on the lips or in the mouth sudden decrease in the amount of urine unusual bleeding or bruising unusual tiredness or weakness yellow eyes or skin Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen: Symptoms of overdose Diarrhea increased sweating loss of appetite nausea or vomiting stomach cramps or pain swelling, pain, or tenderness in the upper abdomen or stomach area For Healthcare Professionals Applies to acetaminophen: compounding powder, intravenous solution, oral capsule, oral granule effervescent, oral liquid, oral powder for reconstitution, oral suspension, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release, rectal suppository General In general, acetaminophen (the active ingredient contained in Topcare 8 Hour Pain Relief) is well-tolerated when administered in therapeutic doses. The most commonly reported adverse reactions have included nausea, vomiting, constipation. Injection site pain and injection site reaction have been reported with the IV product. [ Ref ] Hepatic Common (1% to 10%): Increased aspartate aminotransferase Rare (less than 0.1%): Increased hepatic transaminases Frequency not reported: Liver failure [ Ref ] Gastrointestinal Very common (10% or more): Nausea (up to 34%), Vomiting (up to 15%) Common (1% to 10%): Abdominal pain, diarrhea, constipation, dyspepsia, enlarged abdomen Frequency not reported: Dry mouth [ Ref ] Hypersensitivity Postmarketing reports: Anaphylaxis, hypersensitivity reactions [ Ref ] Hematologic Common (1% to 10%): Anemia, postoperative hemorrhage Very rare (less than 0.01%): Thrombocytopenia, leucopenia, neutropenia [ Ref ] Dermatologic Common (1% to 10%): Rash, pruritus Rare (less than 0.1%): Serious skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysis Very rare (less than 0.01%): Pemphigoid reaction, pustular rash, Lyell syndrome : [ Ref ] Respiratory Common (1% to 10%): Dyspnea, abnormal breath sounds, pulmonary edema, hypoxia, pleural effusion, stridor, wheezing, coughing [ Ref ] Cardiovascular Common (1% to 10%): Peripheral edema, hypertension, hypotension, tachycardia, chest pain [ Ref ] Metabolic Common (1% to 10%): Hypokalemia, hyperglycemia [ Ref ] Nervous system Common (1% to 10%): Headache, dizziness Frequency not reported: Dystonia Musculoskeletal Common (1% to 10%): Muscle spasms, trismus Psychiatric Common (1% to 10%): Insomnia, anxiety Genitourinary Common (1% to 10%): Oliguria Local Common (1% to 10%): Infusion site pain, injection site reactions Ocular Common (1% to 10%): Periorbital edema Other Common (1% to 10%): Pyrexia, fatigue Rare (0.01% to 0.1%): Malaise References 1. "Multum Information Services, Inc. Expert Review Panel" 2. Zimmerman HJ, Maddrey WC "Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure." Hepatology 22 (1995): 767-73 3. Vitols S "Paracetamol hepatotoxicity at therapeutic doses." J Intern Med 253 (2003): 95-8 4. Gursoy M, Haznedaroglu IC, Celik I, Sayinalp N, Ozcebe OI, Dundar SV "Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity." Ann Pharmacother 30 (1996): 762-5 5. Kurtovic J, Riordan SM "Paracetamol-induced hepatotoxicity at recommended dosage." J Intern Med 253 (2003): 240-3 6. McJunkin B, Barwick KW, Little WC, Winfield JB "Fatal massive hepatic necrosis following acetaminophen overdose." JAMA 236 (1976): 1874-5 7. Minton NA, Henry JA, Frankel RJ "Fatal paracetamol poisoning in an epileptic." Hum Toxicol 7 (1988): 33-4 8. Cheung L, Meyer KC "Acetaminophen poisoning and liver function." N Engl J Med 331 (1994): 1311-2 9. Rumore MM, Blaiklock RG "Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity." J Pharm Sci 81 (1992): 203-7 10. Kumar S, Rex DK "Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics." Arch Intern Med 151 (1991): 1189-91 11. Block R, Jankowski JA, Lacoux P, Pennington CR "Does hypothermia protect against the development of hepatitis in paracetamol overdose?" Anaesthesia 47 (1992): 789-91 12. Whitcomb DC, Block GD "Association of acetaminopphen hepatotoxicity with fasting and ethanol use." JAMA 272 (1994): 1845-50 13. Hartleb M "Do thyroid hormones promote hepatotoxicity to acetaminophen?" Am J Gastroenterol 89 (1994): 1269-70 14. Lee WM "Acute liver failure." Am J Med 96 (1994): 3-9 15. Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA "Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen." Arch Intern Med 145 (1985): 2019-23 16. Mofenson HC, Caraccio TR, Nawaz H, Steckler G "Acetaminophen induced pancreatitis." Clin Toxicol 29 (1991): 223-30 17. Singer AJ, Carracio TR, Mofenson HC "The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction." Ann Emerg Med 26 (1995): 49-53 18. Bonkovsky HL "Acetaminophen hepatotoxicity, fasting, and ethanol." JAMA 274 (1995): 301 19. Keays R, Harrison PM, Wendon JA, et al "Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial." BMJ 303 (1991): 1026-9 20. Brotodihardjo AE, Batey RG, Farrell GC, Byth K "Hepatotoxicity from paracetamol self-poisoning in Western Sydney: a continuing challenge." Med J Aust 157 (1992): 382-5 21. Lee WM "Medical progress: drug-induced hepatotoxicity." N Engl J Med 333 (1995): 1118-27 22. Keaton MR "Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion." South Med J 81 (1988): 1163-6 23. Johnson GK, Tolman KG "Chronic liver disease and acetaminophen." Ann Intern Med 87 (1977): 302-4 24. Smilkstein MJ, Douglas Dr, Daya MR "Acetaminophen poisoning and liver function." N Engl J Med 331 (1994): 1310-1 25. Shriner K, Goetz MB "Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6 26. Whitcomb DC "Acetaminophen poisoning and liver function." N Engl J Med 331 (1994): 1311 27. Cheung L, Potts RG, Meyer KC "Acetaminophen treatment nomogram." N Engl J Med 330 (1994): 1907-8 28. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B "Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition - evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency." Hepatology 19 (1994): 1141-8 29. O'Dell JR, Zetterman RK, Burnett DA "Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic." JAMA 255 (1986): 2636-7 30. Block R "Liver failure induced by paracetamol." BMJ 306 (1993): 457 31. Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB "Acetaminophen hepatotoxicity in alcoholics." Ann Intern Med 104 (1986): 399-404 32. Bray GP "Liver failure induced by paracetamol." BMJ 306 (1993): 157-8 33. Wong V, Daly M, Boon A, Heatley V "Paracetamol and acute biliary pain with cholestasis." Lancet 342 (1993): 869 34. Nelson EB, Temple AR "Acetaminophen hepatotoxicity, fasting, and ethanol." JAMA 274 (1995): 301 35. Halevi A, BenAmitai D, Garty BZ "Toxic epidermal necrolysis associated with acetaminophen ingestion." Ann Pharmacother 34 (2000): 32-4 36. Settipane RA, Stevenson DD "Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma." J Allergy Clin Immunol 84 (1989): 26-33 37. Kalyoncu AF "Acetaminophen hypersensitivity and other analgesics." Ann Allergy 72 (1994): 285 38. Doan T, Greenberger PA "Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47- year-old woman." Ann Allergy 70 (1993): 439-44 39. Doan T "Acetaminophen hypersensitivity and other analgesics - response." Ann Allergy 72 (1994): 285 40. Leung R, Plomley R, Czarny D "Paracetamol anaphylaxis." Clin Exp Allergy 22 (1992): 831-3 41. Kawada A, Hiruma M, Noguchi H, Ishibashi A "Fixed drug eruption induced by acetaminophen in a 12-year-old girl." Int J Dermatol 35 (1996): 148-9 42. Van Diem L, Grilliat JP "Anaphylactic shock induced by paracetamol." Eur J Clin Pharmacol 38 (1990): 389-90 43. Bougie DW, Benito AI, Sanchez-Abarca LI, Torres R, Birenbaum J, Aster RH "Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen." Blood 109 (2007): 3608-9 44. Shoenfeld Y, Shaklai M, Livni E, Pinkhas J "Thrombocytopenia from acetaminophen." N Engl J Med 303 (1980): 47 45. Guccione JL, Zemtsov A, Cobos E, Neldner KH "Acquired purpura fulminans induced by alcohol and acetaminophen - successful treatment with heparin and vitamin-k." Arch Dermatol 129 (1993): 1267-9 46. Thomas RH, Munro DD "Fixed drug eruption due to paracetamol." Br J Dermatol 115 (1986): 357-9 47. Filipe PL, Freitas JP, Decastro JC, Silva R "Drug eruption induced by acetaminophen in infectious mononucleosis." Int J Dermatol 34 (1995): 220-1 48. Kondo K, Inoue Y, Hamada H, Yokoyama A, Kohno N, Hiwada K "Acetaminophen-induced eosinophilic pneumonia." Chest 104 (1993): 291-2 49. Brown G "Acetaminophen-induced hypotension." Heart Lung 25 (1996): 137-40 50. Koulouris Z, Tierney MG, Jones G "Metabolic acidosis and coma following a severe acetaminophen overdose." Ann Pharmacother 33 (1999): 1191-4 Some side effects of Topcare 8 Hour Pain Relief may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA . Next Dosage Print this page More about Topcare 8 Hour Pain Relief (acetaminophen) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions 0 Reviews Add your own review/rating Drug class: miscellaneous analgesics Consumer resources Other brands: Tylenol , Paracetamol , Mapap , Tylenol Arthritis Pain , ... +37 more Professional resources Topcare 8 Hour Pain Relief (FDA) Acetaminophen (AHFS Monograph) Related treatment guides Fever Muscle Pain Pain Sciatica Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.} Drug Status Rx OTC Availability Rx and/or OTC C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Miscellaneous analgesics Related Drugs Pain tramadol , acetaminophen , Tylenol , naproxen , oxycodone , More... Sciatica acetaminophen , Tylenol , naproxen , cyclobenzaprine , aspirin , ibuprofen , More... Muscle Pain acetaminophen , Tylenol , naproxen , ibuprofen , diclofenac , Voltaren , More... Fever acetaminophen , Tylenol , naproxen , aspirin , ibuprofen , Aleve , More... Topcare 8 Hour Pain Relief Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first!} } looking forward to
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