keep on with decitabine Generic Name: decitabine (de SIT a been) Brand Name: Dacogen Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons What is decitabine? Decitabine is a cancer medication that interferes with the growth and spread of cancer cells in the body. Decitabine is used to treat myelodysplastic syndromes (certain types of blood or bone marrow cancer). Decitabine may also be used for purposes not listed in this medication guide. Slideshow Leukemia Symptoms And Lessons: Is A Solution In Sight? What is the most important information I should know about decitabine? Decitabine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches). What should I discuss with my health care provider before receiving decitabine? To make sure you can safely take decitabine, tell your doctor if you have any of these other conditions: kidney disease; or liver disease. Do not use decitabine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. If a man fathers a child while using this medication, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Continue using condoms for at least 2 months after you stop receiving decitabine. It is not known whether decitabine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving decitabine. How is decitabine given? Decitabine is injected into a vein through an IV. A healthcare provider will give you this injection. In most cases, a decitabine injection is given every 8 hours for 3 days. This 3-day treatment is usually repeated every 6 weeks. You will most likely receive at least 4 of these treatments. You may be given other medications to prevent nausea or vomiting while you are receiving decitabine. Decitabine can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Your kidney or liver function may also need to be checked. What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your decitabine injection. What happens if I overdose? Since decitabine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving decitabine? Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry. Decitabine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: fever, chills, body aches, cough, sore throat, flu symptoms; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; pale skin, feeling light-headed, rapid heart rate, trouble concentrating; white patches or sores inside your mouth or on your lips; or stabbing chest pain, wheezing, feeling short of breath, cough with yellow or green mucus; swelling, pain, tenderness, or redness anywhere on your body; or electrolyte imbalance (confusion, uneven heart rate, extreme thirst, increased urination, jerking muscle movements, leg discomfort, muscle weakness or limp feeling). Common side effects may include: headache, dizziness, drowsiness; nausea, vomiting, stomach pain, diarrhea, constipation; cough, dry mouth; joint pain; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Decitabine dosing information Usual Adult Dose for Myelodysplastic Syndrome: TREATMENT REGIMEN OPTION 1: 15 mg/m2 IV over 3 hours; repeat every 8 hours for 3 days; repeat this cycle every 6 weeks; patients may be premedicated with standard antiemetic therapy If hematologic recovery (ANC 1,000/mcL or greater and platelets 50,000/mcL or greater) from a previous treatment cycle requires more than 6 weeks, then the next cycle should be delayed and dosing temporarily reduced by following this algorithm: -Recovery requiring more than 6, but less than 8 weeks: Delay dosing for up to 2 weeks and temporarily reduce the dose to 11 mg/m2 IV every 8 hours (33 mg/m2/day, 99 mg/m2/cycle) when restarting therapy -Recovery requiring more than 8, but less than 10 weeks: Assess patient for disease progression (by bone marrow aspirates); in the absence of progression, the dose should be delayed up to 2 more weeks and then reduced to 11 mg/m2 IV every 8 hours (33 mg/m2/day, 99 mg/m2/cycle) when restarting therapy, then maintained or increased in subsequent cycles as clinically indicated TREATMENT REGIMEN OPTION 2: 20 mg/m2 IV over 1 hour; repeat daily for 5 days; repeat this cycle every 4 weeks; patients may be premedicated with standard antiemetic therapy If myelosuppression is present, subsequent treatment cycles should be delayed until there is hematologic recovery (ANC 1,000/mcL or greater and platelets 50,000/mcL or greater) Comments: -With either regimen, it is recommended that patients be treated for a minimum of 4 cycles; however, a complete or partial response may take longer than 4 cycles. -Perform complete blood and platelet counts prior to each cycle and as needed to monitor response and toxicity. -Perform liver chemistries and serum creatinine prior to initiation of therapy. Use: For the treatment of myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups What other drugs will affect decitabine? Other drugs may interact with decitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about decitabine Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: antimetabolites Consumer resources Decitabine Decitabine Intravenous (Advanced Reading) Other brands: Dacogen Professional resources Decitabine (AHFS Monograph) Decitabine (FDA) Decitabine (Wolters Kluwer) Related treatment guides Acute Myeloid Leukemia Myelodysplastic Syndrome Where can I get more information? Your doctor or pharmacist can provide more information about decitabine. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 3.03. Date modified: December 03, 2017 Last reviewed: September 29, 2015} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Dr. Reddy's Laboratories, Inc. Sun Pharmaceutical Industries Inc. Drug Class Antimetabolites Related Drugs Myelodysplastic Syndrome Vidaza , azacitidine , Dacogen , More... Decitabine Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Related Questions & Answers Decitabine - Husband is to start this drug Monday. He has lymphoma and MDS. The last chemo we had? Myelodysplastic Syndrome - Has anyone undergone Dacogen, (Decitabine) treatment for MDS and if so? My husband has just been diagnosed with therapy-related MDS. He is getting decitabine every 4 weeks? Read more questions} } to influence
a number of decitabine adjustments
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