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means Ibuprofen Pregnancy and Breastfeeding Warnings Ibuprofen is also known as: Actiprofen , Addaprin , Advil , Advil Liqui-Gels , Advil Migraine, Caldolor , Children's Motrin , Childrens Ibuprofen Berry, Haltran , IBU , IBU-200 , Ibu-4 , Ibu-8 , Ibu-Tab , Ibuprofen PMR, Menadol, Midol IB , Motrin , Motrin Childrens , Motrin IB , Motrin Infant Drops , Motrin Junior Strength , Nuprin , Proprinal , Rufen Overview Side Effects Dosage Professional Tips More Interactions Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Compare Alternatives Pricing & Coupons Ibuprofen Pregnancy Warnings Not recommended during last trimester of pregnancy. Prior to 30 weeks gestation: Use only if potential benefit justifies the potential risk to the fetus. AU TGA pregnancy category: C US FDA pregnancy category: C Comments: -Avoid use during third trimester as it may cause premature closure of the ductus arteriosus. -Not recommended in women attempting to conceive as may impair female fertility. Animal studies have revealed evidence of increased risk of miscarriage, cardiac malformation, and gastroschisis following use of prostaglandin synthesis inhibitors in early pregnancy. Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) during the third trimester of pregnancy may cause significant adverse effects, including premature closure of the fetal ductus arteriosus, oligohydramnios, fetal renal impairment, pulmonary hypertension, and prolongation of bleeding time. There are no controlled data in human pregnancy. Administration during labor and delivery is not recommended; onset of labor may be delayed and duration increased with greater bleeding tendency in mother and child. NSAIDs may impair female fertility; withdrawal of NSAID therapy should be considered in women with difficulties conceiving or who are undergoing investigation of infertility. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. See references Ibuprofen Breastfeeding Warnings Due to low levels in breast milk, short half-life, and therapeutic administration directly to infants at doses much higher than those excreted in breast milk, use is considered acceptable in nursing mothers; however, according to some manufacturers, use is not recommended. Limited published reports indicate that following oral administration, this drug is present in human milk at relative infant doses of 0.06% to 0.6% of the maternal weight-adjusted daily dose. AU: Use is not recommended. UK and US: Caution is recommended. Excreted into human milk: Yes (in small amounts) Comments: This drug has been used without apparent harmful effects in the nursing infant. See references References for pregnancy information "Product Information. Caldolor (ibuprofen)." Cumberland Pharmaceuticals Inc, Nashville, TN. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. NeoProfen (ibuprofen)." Ovation Pharmaceuticals Inc, Deerfield, IL. Cerner Multum, Inc. "Australian Product Information." O 0 "Product Information. Ibuprofen (ibuprofen)." Par Pharmaceutical Inc, Spring Valley, NY. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI. References for breastfeeding information United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]): "Product Information. NeoProfen (ibuprofen)." Ovation Pharmaceuticals Inc, Deerfield, IL. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI. "Product Information. Caldolor (ibuprofen)." Cumberland Pharmaceuticals Inc, Nashville, TN. Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Ibuprofen (ibuprofen)." Par Pharmaceutical Inc, Spring Valley, NY. Print this page See Also... Ibuprofen use while Breastfeeding (in more detail) Ibuprofen Consumer Information Pregnancy Support Group FDA Pregnancy Categories Medicine use during Pregnancy Medicine use while Breastfeeding Safe Medications during Breastfeeding Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist. Drug Status Rx OTC Availability Rx and/or OTC Pregnancy Category Risk depends on usage N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Ibuprofen Rating 114 User Reviews 7.5 /10 114 User Reviews 7.5 Rate it! Drug Class Nonsteroidal anti-inflammatory agents Related Questions & Answers Can I take aspirin, ibuprofen or paracetamol along with tramadol? Can you take Ibuprofen and Toradol together? Is ibuprofen (Advil) a blood thinner? Acetaminophen vs ibuprofen: What's the difference? Can you take ibuprofen while pregnant? Read more questions superb


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