ward off romidepsin (Intravenous route) roe-mi-DEP-sin Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Istodax Available Dosage Forms: Powder for Solution Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Histone Deacetylase Inhibitor Slideshow Men's Health Month And Movember: Raising The Profile Of Men's Health One Stache At A Time Uses For romidepsin Romidepsin injection is used to treat certain types of cancer of the white blood cells called cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL). romidepsin is used in a patient who has already been treated with other medicines. Romidepsin interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. Before you begin treatment with romidepsin, you and your doctor should talk about the benefits of romidepsin as well as the risks of using it. romidepsin is to be given only by or under the direct supervision of a doctor. Before Using romidepsin In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For romidepsin, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to romidepsin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of romidepsin injection in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of romidepsin injection in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving romidepsin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using romidepsin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Atazanavir Boceprevir Cobicistat Lopinavir Nelfinavir Ritonavir Saquinavir Telaprevir Tipranavir Using romidepsin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Carbamazepine Clarithromycin Conivaptan Dexamethasone Eliglustat Enzalutamide Fosphenytoin Idelalisib Indinavir Itraconazole Ketoconazole Mitotane Nefazodone Phenytoin Posaconazole Primidone Rifabutin Rifampin Rifapentine Simeprevir St John's Wort Telithromycin Voriconazole Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using romidepsin with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use romidepsin, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of romidepsin. Make sure you tell your doctor if you have any other medical problems, especially: Anemia or Blood or bone marrow problems or Epstein Barr infection (mononucleosis), history of or Hepatitis B infection, history of or Leukopenia (low white blood cells) or Thrombocytopenia (low platelets) Use with caution. May make these conditions worse. Congenital long QT syndrome (heart rhythm problem) or Heart or blood vessel disease or Heart rhythm problems, history of or Hypokalemia (low potassium in the blood) or Hypomagnesemia (low magnesium in the blood) Use with caution. May make side effects become worse. Infection May decrease your body's ability to fight an infection. Kidney disease, severe or Liver disease, moderate or severe Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of romidepsin You will receive romidepsin while you are in a hospital or cancer treatment center. romidepsin is given through a needle placed in one of your veins. romidepsin comes with a patient information leaflet. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand. Precautions While Using romidepsin It is very important that your doctor check your progress at regular visits to make sure romidepsin is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects. Using romidepsin while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Romidepsin can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding: If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur. You may get infections more easily while using romidepsin. These can occur during treatment and within 30 days after the last dose. Tell your doctor right away if you have a fever, cough, shortness of breath, burning on urination, flu-like symptoms, muscle aches, or worsening skin problems. romidepsin may cause heart rhythm changes, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects. Contact your doctor right away if you have fast, pounding, or uneven heartbeats, chest pain, or shortness of breath. romidepsin may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness. Cancer medicines can cause nausea and/or vomiting even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. romidepsin Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Abdominal or stomach cramps or pain black, tarry stools bleeding gums blood in the urine or stools blurred vision bone pain chest pain chills confusion convulsions cough or hoarseness decreased urine output difficulty with breathing dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position drowsiness dry mouth fast or irregular heartbeat fever flushed, dry skin fruit-like breath odor headache increased hunger increased thirst increased urination joint pain, stiffness, or swelling loss of appetite lower back or side pain muscle cramps in the hands, arms, feet, legs, or face muscle spasms or twitching nausea or vomiting numbness or tingling in the hands, fingertips, feet, or lips painful or difficult urination pale skin pinpoint red spots on the skin seizures sore throat sores, ulcers, or white spots on the lips or in the mouth sweating swelling of the face, ankles, feet, lower legs, or hands swollen glands tremor troubled breathing unexplained weight loss unusual bleeding or bruising unusual tiredness or weakness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Change in taste constipation cracks in the skin diarrhea itching lack or loss of strength loss of appetite loss of heat from the body loss of taste red, swollen skin scaly skin weight loss Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about romidepsin Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 1 Review Add your own review/rating Drug class: histone deacetylase inhibitors Consumer resources Romidepsin Other brands: Istodax Professional resources Romidepsin (AHFS Monograph) RomiDEPsin (Wolters Kluwer) Related treatment guides Cutaneous T-cell Lymphoma Peripheral T-cell Lymphoma} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Histone deacetylase inhibitors Related Drugs Peripheral T-cell Lymphoma Folotyn , romidepsin , Istodax , belinostat , Beleodaq , pralatrexate , More... Cutaneous T-cell Lymphoma bexarotene , Targretin , romidepsin , methoxsalen , Zolinza , Uvadex , Actimmune , vorinostat , Targretin Gel , Istodax , interferon gamma-1b , More... 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