health practitioner Parameters of Norgestimate and Ethinyl Estradiol During a Three Cycle Study Analyte Cycle Day C max t max (h) AUC 0-24h t 1/2 (h) NGMN 3 7 1.80 (0.46) 1.42 (0.73) 15 (3.88) NC 14 2.12 (0.56) 1.21 (0.26) 16.1 (4.97) NC 21 2.66 (0.47) 1.29 (0.26) 21.4 (3.46) 22.3 (6.54) NG 3 7 1.94 (0.82) 3.15 (4.05) 34.8 (16.5) NC 14 3 (1.04) 2.21 (2.03) 55.2 (23.5) NC 21 3.66 (1.15) 2.58 (2.97) 69.3 (23.8) 40.2 (15.4) EE 3 7 124 (39.5) 1.27 (0.26) 1130 (420) NC 14 128 (38.4) 1.32 (0.25) 1130 (324) NC 21 126 (34.7) 1.31 (0.56) 1090 (359) 15.9 (4.39) Food Effect The effect of food on the pharmacokinetics of norgestimate and ethinyl estradiol has not been studied. Distribution NGMN and NG are highly bound (>97%) to serum proteins. NGMN is bound to albumin and not to SHBG nowadays
Photo :Parameters of Norgestimate and Ethinyl Estradiol During a Three Cycle Study Analyte Cycle Day C max t max (h) AUC 0-24h t 1/2 (h) NGMN 3 7 1.80 (0.46) 1.42 (0.73) 15 (3.88) NC 14 2.12 (0.56) 1.21 (0.26) 16.1 (4.97) NC 21 2.66 (0.47) 1.29 (0.26) 21.4 (3.46) 22.3 (6.54) NG 3 7 1.94 (0.82) 3.15 (4.05) 34.8 (16.5) NC 14 3 (1.04) 2.21 (2.03) 55.2 (23.5) NC 21 3.66 (1.15) 2.58 (2.97) 69.3 (23.8) 40.2 (15.4) EE 3 7 124 (39.5) 1.27 (0.26) 1130 (420) NC 14 128 (38.4) 1.32 (0.25) 1130 (324) NC 21 126 (34.7) 1.31 (0.56) 1090 (359) 15.9 (4.39) Food Effect The effect of food on the pharmacokinetics of norgestimate and ethinyl estradiol has not been studied. Distribution NGMN and NG are highly bound (>97%) to serum proteins. NGMN is bound to albumin and not to SHBG have the opportunity while NG is bound primarily to SHBG. EE is extensively bound (>97%) to serum albumin and induces an increase in the serum concentrations of SHBG. Metabolism NGM is extensively metabolized by first-pass mechanisms in the gastrointestinal tract and/or liver. NGM's primary active metabolite is NGMN. Subsequent hepatic metabolism of NGMN occurs and metabolites include NG is legendary
fundamental Parameters of Norgestimate and Ethinyl Estradiol During a Three Cycle Study Analyte Cycle Day C max t max (h) AUC 0-24h t 1/2 (h) NGMN 3 7 1.80 (0.46) 1.42 (0.73) 15 (3.88) NC 14 2.12 (0.56) 1.21 (0.26) 16.1 (4.97) NC 21 2.66 (0.47) 1.29 (0.26) 21.4 (3.46) 22.3 (6.54) NG 3 7 1.94 (0.82) 3.15 (4.05) 34.8 (16.5) NC 14 3 (1.04) 2.21 (2.03) 55.2 (23.5) NC 21 3.66 (1.15) 2.58 (2.97) 69.3 (23.8) 40.2 (15.4) EE 3 7 124 (39.5) 1.27 (0.26) 1130 (420) NC 14 128 (38.4) 1.32 (0.25) 1130 (324) NC 21 126 (34.7) 1.31 (0.56) 1090 (359) 15.9 (4.39) Food Effect The effect of food on the pharmacokinetics of norgestimate and ethinyl estradiol has not been studied. Distribution NGMN and NG are highly bound (>97%) to serum proteins. NGMN is bound to albumin and not to SHBG to accentuate
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