positive factors erlotinib Generic Name: erlotinib (er LOE ti nib) Brand Name: Tarceva Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A What is erlotinib? Erlotinib is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body. Erlotinib is used to treat non-small cell lung cancer or pancreatic cancer that has spread to other parts of the body (metastatic). Erlotinib is usually given after other cancer medicines have been tried without success. Erlotinib may also be used for purposes not listed in this medication guide. Slideshow Looking Ahead: New Drug Approvals for 2017 What is the most important information I should know about erlotinib? Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. What should I discuss with my healthcare provider before taking erlotinib? You should not take erlotinib if you are allergic to it. To make sure erlotinib is safe for you, tell your doctor if you have: lung or breathing problems (other than lung cancer); kidney disease; liver disease; a history of stomach bleeding; eye problems; if you are dehydrated; if you smoke; or if you also take warfarin (Coumadin, Jantoven). Do not take erlotinib if you are pregnant. It could harm the unborn baby. Use effective birth control while you are taking this medication and for at least 1 month after your last dose. It is not known whether erlotinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while taking erlotinib. How should I take erlotinib? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take erlotinib on an empty stomach, at least 1 hour before or 2 hours after eating. You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember (take only on an empty stomach). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe diarrhea or severe skin rash. What should I avoid while using erlotinib? Avoid taking an antacid within several hours before or after you take erlotinib. Ask a doctor or pharmacist before taking other stomach medicines such as cimetidine (Tagamet) or ranitidine (Zantac). Avoid exposure to sunlight or tanning beds. Erlotinib can cause skin rash, dryness, or other irritation. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Avoid using skin products that can cause dryness or irritation, such as acne medications, harsh soaps or skin cleansers, or skin products that contain alcohol. Avoid smoking. It can make erlotinib less effective. Grapefruit and grapefruit juice may interact with erlotinib and lead to unwanted side effects. Avoid the use of grapefruit products while taking erlotinib. Avoid taking an herbal supplement containing St. John's wort at the same time you are taking erlotinib. This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry. Erlotinib side effects Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using erlotinib and call your doctor at once if you have: sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath; severe stomach pain, fever, chills, coughing up blood; severe ongoing nausea, vomiting, or diarrhea; eye pain or irritation, vision problems; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; kidney or liver problems--little or no urinating; swelling, rapid weight gain (especially in your face and midsection); confusion, nausea, vomiting, dark urine, or jaundice (yellowing of the skin or eyes); or severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Common side effects may include: nausea, vomiting, diarrhea, loss of appetite; dry eyes; cough, trouble breathing; rash; or weakness, tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Erlotinib dosing information Usual Adult Dose for Non-Small Cell Lung Cancer: 150 mg orally once a day Duration of therapy: Until disease progression or unacceptable toxicity Comments: -There is no evidence that treatment beyond disease progression is beneficial. Uses: -First-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations. -Maintenance treatment of patients with locally advanced or metastatic NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy. -Treatment of locally advanced or metastatic NSCLC after failure of at least one prior chemotherapy regimen. Usual Adult Dose for Pancreatic Cancer: 100 mg orally once a day Duration of therapy: Until disease progression or unacceptable toxicity Use: First-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer, in combination with gemcitabine. What other drugs will affect erlotinib? Many drugs can interact with erlotinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with erlotinib. Give a list of all your medicines to any healthcare provider who treats you. Next Side Effects Print this page Add to My Med List More about erlotinib Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 39 Reviews Add your own review/rating Drug class: EGFR inhibitors Consumer resources Erlotinib Erlotinib (Advanced Reading) Other brands: Tarceva Professional resources Erlotinib (AHFS Monograph) Erlotinib (Wolters Kluwer) Related treatment guides Pancreatic Cancer Renal Cell Carcinoma Non-Small Cell Lung Cancer Where can I get more information? Your pharmacist can provide more information about erlotinib. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 6.05. Date modified: December 03, 2017 Last reviewed: November 01, 2016} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class EGFR inhibitors Related Drugs Non-Small Cell Lung Cancer Avastin , methotrexate , Taxol , Opdivo , cisplatin , Taxotere , Tarceva , Keytruda , paclitaxel , nivolumab , gemcitabine , Gemzar , More... Pancreatic Cancer fluorouracil , Tarceva , gemcitabine , Gemzar , Abraxane , Afinitor , Sutent , mitomycin , everolimus , sunitinib , streptozocin , paclitaxel protein-bound , More... Erlotinib Rating 39 User Reviews 8.8 /10 39 User Reviews 8.8 Rate it! Related Questions & Answers Does anybody know how efficient is generic Erlotinib vs Tarceva? Tarceva and Iscador? Erlotinib - How can anyone afford Tarceva? My co-pay would be $2500.00. How? Hi... my father has completed 60 tablets of erlotinib... past few days he has been feeling severely? 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