that you can imagine [25 C.:<8 C. j May be stored at room temperature for short periods of time (i.e.,> <60 days). j Protect from light. a Methylergonovine maleate: 2 8 C. b Protect from light. a b Compatibility For information on systemic interactions resulting from concomitant use, see Interactions. Drug Compatibility Y-Site Compatibility for Methylergonovine MaleateHID Compatible Heparin sodium Hydrocortisone sodium succinate Potassium chloride Vitamin B complex with C Actions Directly stimulates contractions of uterine and vascular smooth muscle. a b Increases the amplitude and frequency of uterine contractions and uterine tone which in turn impedes uterine blood flow. a Induces a rapid and sustained tetanic uterotonic effect. b Produces vasoconstriction. a Advice to Patients Importance of women informing clinicians if they plan to breast-feed. b Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses. b Importance of informing patients of other important precautionary information. b (See Cautions.) Preparations Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Ergonovine Maleate Routes Dosage Forms Strengths Brand Names Manufacturer Oral Tablets 0.2 mg Ergotrate (with povidone) Pharmacist Pharmaceutical Parenteral Injection 0.2 mg/mL Ergotrate Pharmacist Pharmaceutical Methylergonovine Maleate Routes Dosage Forms Strengths Brand Names Manufacturer Oral Tablets 0.2 mg Methergine (with parabens and povidone) Novartis Parenteral Injection 0.2 mg/mL Methergine Novartis AHFS DI Essentials. Copyright 2017, Selected Revisions January 1, 2008. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. † Use is not currently included in the labeling approved by the US Food and Drug Administration. References a. AHFS drug information 2004. McEvoy GK, ed. Ergonovine Maleate and Methylergonovine Maleate. Bethesda, MD: American Society of Health-System Pharmacists; 2007: 3269-70. b. Novartis. Methergine (methylergonovine maleate) tablets and injection prescribing information. East Hanover, NJ; 2007 Apr. c. Briggs GG, Wan SR. Drug therapy during labor and delivery, part 2. Am J Health-Syst Pharm . 2006; 63:1131-9. [PubMed 16754739] d. American College of Obstetricians and Gynecologists (ACOG) Committee Practice Bulletin. Postpartum hemorrhage. Practice Bulletin No. 76. Washington, DC: American College of Obstetricians and Gynecologists; 2006 Oct. e. Liabsuetrakul T, Choobun T, Peeyananjarassri K, Islam QM. Prophylactic use of ergot alkaloids in the third stage of labour. Cochrane Database Syst Rev . 2007; 2:CD005456. f. Mousa HA, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev . 2007; 1:CD003249. g. Perinatal HIV Guidelines Working Group. Public Health Service task force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States (October 12, 2006). From the US Department of Health and Human Services HIV/AIDS Information Services (AIDSinfo) website . h. Vogel D, Burkhardt T, Rentsch K et al. Misoprostol versus methylergometrine: pharmacokinetics in human milk. Am J Obstet Gynecol . 2004; 191:2168-73. [PubMed 15592308] i. Pharmacist Pharmaceutical. Ergotrate (ergonovine maleate) tablets prescribing information. Salem, VA; 2007 Mar. j. Pharmacist Pharmaceutical. Ergotrate (ergonovine maleate) injection prescribing information. Salem, VA; 2007 May 29. k. deGroot AN, Vree TB, Hekster YA et al. Pharmacokinetics and bioavailability of oral ergometrine in male volunteers. Biopharm Drug Dispos . 1994; 15:65-73. [PubMed 8161717] l. GlaxoSmithKline. Lexiva (fosamprenavir calcium) tablets and oral suspension prescribing information. Research Triangle Park, NC; 2007 Oct. m. Pfizer. Rescriptor (delavirdine mesylate) tablets prescribing information. La Jolla, CA; 2006 Feb. n. Bristol-Myers Squibb Company. Sustiva (efavirenz) capsules and tablets prescribing information. Princeton, NJ; 2007 Jan. o. Panel on Clinical Practices for Treatment of HIV infection of the Department of Health and Human Services (DHHS). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents (October 10, 2006). From the US Department of Health and Human Services HIV/AIDS Information Services (AIDSinfo) website (). HID. Trissel LA. Handbook on injectable drugs. 14th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2007:1095-6. 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