hold [1%:<2 weeks); may present as sudden headache, vomiting, visual or mental status changes, and infrequently cardiovascular collapse; immediate medical attention may be required. Psychiatric events: Emotional lability, such as crying, irritability, impatience, anger, and aggression, has been reported in patients taking GnRH agonists. Depression, including rare reports of suicidal ideation and attempt, has been reported for GnRH agonists in children treated for CPP; many of these patients had a history of psychiatric illness or other comorbidities with an increased risk of depression. Monitor for development or worsening of psychiatric symptoms, including depression, during treatment. Seizures: Have been observed in patients receiving GnRH agonists; patients with a history of seizures, cerebrovascular disorders, CNS anomalies/tumors, and patients on concomitant medications that have been associated with seizures are at increased risk; has also been reported in patients without risk factors. Disease-related concerns: CPP use: When used for the treatment of CPP, some signs of puberty (eg vaginal bleeding, breast enlargement) may occur but should resolve within the first 2 months of therapy. Other warnings/precautions: Appropriate use: Endometriosis: Experience with nafarelin for the management of endometriosis has been limited to women 18 years and older treated for 6 months; retreatment is not recommended since safety data is not available for use >6 months. Monitoring Parameters CPP: Bone mineral density, GnRH testing (blood LH and FSH levels), measurement of bone age, Tanner staging; monitor for development or worsening of psychiatric symptoms, including depression. Endometriosis: Menstruation, vaginal bleeding or spotting which persists after 2 months of treatment Pregnancy Risk Factor X Pregnancy Considerations Adverse events were observed in some animal reproduction studies. Use is contraindicated in pregnant women and pregnancy should be excluded prior to initiating treatment. Ovulation is inhibited and menstruation is stopped when used appropriately for the treatment of endometriosis, however contraception is not assured. Nonhormonal contraception is recommended. There is no evidence that pregnancy rates are enhanced or adversely affected by use. Patient Education Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?) Patient may experience headache, hot flashes, acne, muscle pain, weight gain, vaginal irritation, rhinorrhea, decreased libido, enlarged breasts, change in body odor, or signs of puberty. Have patient report immediately to prescriber angina, severe rhinitis, menstruation, mood changes, behavioral changes, shortness of breath, abdominal pain, swelling of arms or legs, vaginal discharge, abnormal vaginal bleeding, bone pain, seizures, or signs of pituitary apoplexy (sudden headache, vomiting, passing out, mood changes, eye weakness, unable to move eyes, or vision changes) (HCAHPS). Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients. Next Pregnancy Warnings Print this page Add to My Med List More about nafarelin Side Effects During Pregnancy Dosage Information Support Group En Español 2 Reviews Add your own review/rating Drug class: gonadotropin releasing hormones Consumer resources Nafarelin nasal Nafarelin Nafarelin Nasal (Advanced Reading) Professional resources Nafarelin Acetate (AHFS Monograph) Other brands: Synarel Related treatment guides Endometriosis Precocious Puberty> ] Drug Status Rx Availability Prescription only X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug Nafarelin Rating 2 User Reviews 6.3 /10 2 User Reviews 6.3 Rate it! Drug Class Gonadotropin releasing hormones Related Drugs gonadotropin releasing hormones Lupron , Eligard , leuprolide , Lupron Depot , Trelstar , Zoladex Endometriosis medroxyprogesterone , leuprolide , Provera , Depo-Provera , Lupron Depot , norethindrone , Sprintec , Zoladex , Ortho Tri-Cyclen , danazol , TriNessa , Mononessa , More... Precocious Puberty tamoxifen , Lupron , leuprolide , Nolvadex , triptorelin , histrelin , Vantas , Triptodur , More... great
venture Nafarelin the reality
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