service provider atovaquone and proguanil (Oral route) a-TOE-va-kwone, proe-GWAHN-il hye-droe-KLOR-ide Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Malarone Malarone Pediatric Available Dosage Forms: Tablet Therapeutic Class: Ubiquinone/Biguanide Combination Pharmacologic Class: Proguanil Chemical Class: Ubiquinone Slideshow It s Buggin Me! How to Safely Use an Insect Repellent Uses For atovaquone and proguanil Antiprotozoals are medicines that are used to prevent and treat malaria, a red blood cell infection transmitted by the bite of a mosquito. atovaquone and proguanil is a combination of two medicines, atovaquone and proguanil. atovaquone and proguanil is available only with your doctor's prescription. Before Using atovaquone and proguanil In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For atovaquone and proguanil, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to atovaquone and proguanil or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Studies on atovaquone and proguanil have been done only in patients who weigh more than 25 pounds (11 kilograms [kg]) for the prevention of malaria and more than 11 pounds (5 kg) for the treatment of malaria. There is no specific information comparing use of atovaquone and proguanil combination in patients of lesser weight. Geriatric Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of atovaquone and proguanil in the elderly with use in other age groups. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking atovaquone and proguanil, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using atovaquone and proguanil with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Aurothioglucose Using atovaquone and proguanil with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Cholera Vaccine, Live Dicumarol Efavirenz Rifabutin Rifampin Warfarin Using atovaquone and proguanil with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Chloroquine Indinavir Tetracycline Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of atovaquone and proguanil. Make sure you tell your doctor if you have any other medical problems, especially: Diarrhea or vomiting The amount of atovaquone and proguanil the body can absorb may be decreased. Kidney disease or failure Atovaquone and proguanil could cause your condition to become much worse. Return of previously treated malaria Atovaquone and proguanil may not work in treating the malaria again; your doctor may need to give you another type of medicine Proper Use of atovaquone and proguanil Be sure to take atovaquone and proguanil at the same time each day. Take atovaquone and proguanil with food or with a milky drink. This will help your body absorb the maximal amount of medicine. If you vomit within 1 hour of taking atovaquone and proguanil, take the entire dose again as soon as your stomach can tolerate it. If you or your child has trouble swallowing tablets, you may crush and mix atovaquone and proguanil with condensed milk just before taking it or giving it to your child. Dosing The dose of atovaquone and proguanil will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of atovaquone and proguanil. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For malaria prevention: Adults 250 milligrams (mg) of atovaquone and 100 mg proguanil (1 adult strength tablet) per day, starting 1 to 2 days before entering malarial area and continuing for 7 days following return. Children weighing 25 pounds (11 kilograms [kg]) or more Dosage is according to weight and will be determined by your doctor. Children weighing less than 25 pounds (11 kg) Use and dose must be determined by your doctor. For malaria treatment: Adults 1 gram of atovaquone and 400 mg of proguanil (4 adult strength tablets) once daily as a single dose taken three days in a row. Children weighing 11 pounds (5 kg) or more Dosage is based on body weight and must be determined by your doctor. Children weighing less than 11 pounds (5 kg) Use and dose must be determined by your doctor. Missed Dose If you miss a dose of atovaquone and proguanil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Call your doctor or pharmacist for instructions. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using atovaquone and proguanil Malaria is spread by the bites of certain kinds of infected female mosquitoes. If you are living in, or will be traveling to, an area where there is a chance of getting malaria, the following mosquito-control measures will help to prevent infection: Remain in air-conditioned or well-screened rooms to reduce contact with mosquitoes. If possible, sleep under mosquito netting, preferably netting coated or soaked with permethrin, to avoid being bitten by malaria-carrying mosquitoes. Wear long-sleeved shirts or blouses and long trousers to protect your arms and legs, especially from dusk through dawn when mosquitoes are out. Apply mosquito repellent, preferably one containing DEET, to uncovered areas of the skin from dusk through dawn when mosquitoes are out. Use a pyrethrum-containing flying insect spray to kill mosquitoes in living and sleeping quarters during evening and nighttime hours. Contact your doctor right away if you experience cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips or tongue, shortness of breath, skin rash, tightness in chest, unusual tiredness or weakness, or wheezing. These could be symptoms of an allergic reaction. Atovaquone and proguanil may cause your skin to be more sensitive to sunlight than it is normally. Be sure to wear protective clothing and a hat or apply a product to the skin that prevents sunburn before going outside. atovaquone and proguanil Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur: Incidence not known Blistering, peeling, loosening of skin chills convulsions difficulty swallowing fast heartbeat hives or welts increased sensitivity of skin to sunlight itching, redness or other discoloration of skin joint or muscle pain large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs loss of bladder control muscle spasm or jerking of all extremities puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue rash red, irritated eyes red skin lesions, often with a purple center seeing, hearing, or feeling things that are not there severe mental changes severe sunburn shortness of breath skin rash sores, ulcers or white spots in mouth or on lips sudden loss of consciousness tightness in chest unusual tiredness or weakness wheezing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal pain back pain coughing diarrhea dreams fever headache itching skin lack of or loss of strength nausea muscle pain sore throat sores in mouth sneezing vomiting Less common Acid or sour stomach belching blurred or loss of vision disturbed color perception dizziness double vision flu like symptoms halos around lights heartburn indigestion loss of appetite night blindness overbright appearance of lights sleeplessness stomach discomfort, upset or pain trouble sleeping tunnel vision unable to sleep weight loss Rare Discouragement fear feeling sad or empty irritability lack of appetite loss of interest or pleasure nervousness trouble concentrating Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about atovaquone/proguanil Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 24 Reviews Add your own review/rating Drug class: antimalarial combinations Consumer resources Atovaquone and proguanil Other brands: Malarone , Malarone Pediatric Professional resources Atovaquone and Proguanil Hydrochloride (AHFS Monograph) Atovaquone and Proguanil (FDA) Atovaquone and Proguanil (Wolters Kluwer) Related treatment guides Malaria Prevention Malaria} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Mylan Pharmaceuticals Inc. Prasco Laboratories Glenmark Pharmaceuticals Inc., USA Drug Class Antimalarial combinations Related Drugs Malaria Prevention doxycycline , hydroxychloroquine , Plaquenil , Vibramycin , Malarone , Monodox , mefloquine , atovaquone / proguanil , Doryx , pyrimethamine , More... Malaria doxycycline , hydroxychloroquine , clindamycin , Plaquenil , Cleocin , Vibramycin , quinine , Malarone , atovaquone , Monodox , quinidine , More... Atovaquone / proguanil Rating 24 User Reviews 5.9 /10 24 User Reviews 5.9 Rate it! Atovaquone / proguanil Images Atovaquone / proguanil systemic 250 mg / 100 mg (G 404) View all images Related Questions & Answers Atovaquone/Proguanil - Does this medication need to be taken each time you travel or is it good for? Read more questions} } one of these
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