overseas atovaquone Generic Name: atovaquone (a TOE va kwone) Brand Name: Mepron Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Pricing & Coupons What is atovaquone? Atovaquone is a medication that interferes with the reproduction of protozoa (single-cell organisms) that can cause disease in the body. Atovaquone is used to treat or prevent pneumonia caused by a fungal infection called Pneumocystitis carinii (also called Pneumocystis jiroveci). Atovaquone may also be used for other purposes not listed in this medication guide. Slideshow It s Buggin Me! How to Safely Use an Insect Repellent What is the most important information I should know about atovaquone? You should not use this medication if you are allergic to atovaquone. Before using this medication, tell your doctor if you have liver disease, or a stomach or intestinal disorder. Also tell your doctor if you use other medications such as rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate, Rimactane), a blood thinner such as warfarin (Coumadin), or a seizure medication such as carbamazepine (Carbatrol, Tegretol), divalproex (Depakote), phenytoin (Dilantin), or valproic acid (Depakene). Take atovaquone with a meal for best results. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Call your doctor at once if you have a serious side effect such as easy bruising or bleeding, fever, flu symptoms, white patches in your mouth or throat, worsening cough, wheezing, trouble breathing, a severe red or peeling skin rash, or jaundice (yellowing of the skin or eyes). What should I discuss with my healthcare provider before taking atovaquone? You should not use this medication if you are allergic to atovaquone. If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before you take atovaquone, tell your doctor if you have: liver disease; or a stomach or intestinal disorder. FDA pregnancy category C. It is not known whether atovaquone is harmful to an unborn baby. Before you take atovaquone, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether atovaquone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take atovaquone? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Take atovaquone with a meal for best results. Shake the liquid medicine bottle well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. If you are taking a pre-measured atovaquone dose from a foil pouch, tear open the pouch along the perforated line and take all of the medicine in the pouch. You may drink it directly from the pouch or pour it into a spoon or cup before taking. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Store atovaquone at cool room temperature away from moisture and heat. Do not allow the medicine to freeze. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an atovaquone overdose are not known. What should I avoid while taking atovaquone? Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using this medication. Atovaquone side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: easy bruising or bleeding, unusual weakness; fever, flu symptoms; white patches in your mouth or throat; worsening cough; bronchospasm (wheezing, chest tightness, trouble breathing); fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or nausea, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious side effects may include: mild nausea, vomiting, stomach pain or upset, diarrhea, constipation; headache; weakness, dizziness; muscle pain; mild skin rash; sweating; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Atovaquone dosing information Usual Adult Dose for Pneumocystis Pneumonia: 750 mg orally twice a day for 21 days Alternative therapy may be needed if arterial blood gas values do not improve or worsen after 7 to 10 days of therapy, or if the clinical status declines after 4 days. Usual Adult Dose for Pneumocystis Pneumonia Prophylaxis: 1500 mg orally once a day Usual Adult Dose for Babesiosis: 750 mg orally twice a day with azithromycin (500 to 600 mg on day 1, followed by 250 to 600 mg once a day thereafter or 1000 mg once a day for 3 days, followed by 500 mg once a day thereafter) for 7 to 10 days Usual Adult Dose for Malaria: 500 to 750 mg orally every 12 hours for 7 days; should be used in combination with other antimalarial agents Usual Adult Dose for Toxoplasmosis: 750 mg orally every 6 hours for 2 to 6 months Similar doses given every 6 to 8 hours are used for toxoplasmosis maintenance therapy. Atovaquone is considered second-line therapy for toxoplasmosis. It should be administered in combination with pyrimethamine and leucovorin, with sulfadiazine, or as a single agent in patients intolerant of pyrimethamine with sulfadiazine. Usual Pediatric Dose for Pneumocystis Pneumonia: 1 month to 12 years: 20 mg/kg orally twice a day 13 years or older: 750 mg orally twice a day for 21 days Maximum dose: 1500 mg/day Usual Pediatric Dose for Pneumocystis Pneumonia Prophylaxis: 1 to 3 months: 30 mg/kg orally once a day 4 months up to 2 years: 45 mg/kg orally once a day 2 to 12 years: 30 mg/kg orally once a day 13 years or older: 1500 mg orally once a day Maximum dose: 1500 mg/day Usual Pediatric Dose for Babesiosis: 1 to 12 years: 20 mg/kg orally twice a day with azithromycin (12 mg/kg once a day) for 7 to 10 days 13 years or older: 750 mg orally twice a day with azithromycin (500 to 600 mg on day 1, followed by 250 to 600 mg once a day thereafter or 1000 mg once a day for 3 days, followed by 500 mg once a day thereafter) for 7 to 10 days Maximum dose: 1500 mg/day What other drugs will affect atovaquone? Tell your doctor about all other medications you are using, especially: carbamazepine (Carbatrol, Tegretol); clozapine (Clozaril, FazaClo); rifabutin (Mycobutin); or rifampin (Rifadin, Rifater, Rifamate, Rimactane). This list is not complete and there may be other drugs that can interact with atovaquone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor. Next Side Effects Print this page Add to My Med List More about atovaquone Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 3 Reviews Add your own review/rating Drug class: miscellaneous antibiotics Consumer resources Atovaquone Atovaquone (Advanced Reading) Other brands: Mepron Professional resources Atovaquone (AHFS Monograph) Atovaquone Suspension (FDA) Atovaquone (Wolters Kluwer) Related treatment guides Babesiosis Malaria Pneumocystis Pneumonia Prophylaxis Pneumocystis Pneumonia Toxoplasmosis Where can I get more information? Your pharmacist can provide more information about atovaquone. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 3.03. Last reviewed: December 15, 2010 Date modified: December 03, 2017} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Amneal Pharmaceuticals LLC Drug Class Miscellaneous antibiotics Related Drugs Babesiosis azithromycin , Zithromax , clindamycin , Cleocin , Mepron , More... Pneumocystis Pneumonia clindamycin , Bactrim , sulfamethoxazole / trimethoprim , Bactrim DS , leucovorin , More... Toxoplasmosis azithromycin , Zithromax , clindamycin , Bactrim , sulfamethoxazole / trimethoprim , More... Malaria doxycycline , hydroxychloroquine , clindamycin , Plaquenil , Cleocin , More... 1 more conditions... Atovaquone Rating 3 User Reviews 5.5 /10 3 User Reviews 5.5 Rate it! Related Questions & Answers Atovaquone/proguanil & alcohol? Atovaquone/Proguanil - Does this medication need to be taken each time you travel or is it good for? Read more questions} } unhurt
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