gifting away Tolcapone Side Effects Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons For the Consumer Applies to tolcapone: oral tablet Along with its needed effects, tolcapone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking tolcapone: Incidence not known Dark urine itching light-colored stools loss of appetite nausea (continuing) tenderness in upper right part of abdomen unusual drowsiness, dullness, or feeling sluggish unusual tiredness or weakness yellow eyes or skin Check with your doctor as soon as possible if any of the following side effects occur while taking tolcapone: More common Abdominal pain cough diarrhea dizziness dizziness or lightheadedness when getting up from a lying or sitting position drowsiness fainting fever hallucinations (seeing, hearing, or feeling things that are not there) headache nasal congestion (stuffy nose) nausea runny nose sneezing sore throat trouble in sleeping twitching, twisting, or other unusual body movements vomiting Less common Absence of or decrease in body movement blood in urine chest pain chills confusion falling general feeling of discomfort or illness hyperactivity loss of balance control muscle pain troubled breathing Rare Agitation bloody or cloudy urine burning of feet burning, prickling, or tingling sensations chest discomfort difficult or painful urination difficulty in thinking or concentrating frequent urge to urinate irritability joint pain, redness, or swelling low blood pressure muscle cramps neck pain stiffness Some side effects of tolcapone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Constipation dryness of mouth excessive dreaming increased sweating Less common Bleeding difficulty in sleeping excessive muscle tone fever heartburn gas muscle stiffness muscle tension or tightness trouble in holding or releasing urine After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects: Confusion fever muscle rigidity For Healthcare Professionals Applies to tolcapone: oral tablet General In general, tolcapone was well tolerated in clinical trials with most adverse events being mild to moderate in severity. Dyskinesia and other dopaminergic-related effects were the most frequently reported adverse events in patients with motor fluctuations. Diarrhea was the most common nondopaminergic adverse event, occurring in up to 26% of patients who received tolcapone, and necessitating discontinuation of treatment in approximately 5% to 10% of patients. [ Ref ] Hepatic Hepatic side effects have included severe liver damage, including fulminant liver failure resulting in death. Three cases of fatal fulminant hepatic failure have been reported from more than 40,000 patient years of worldwide use. Increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) have also been reported. [ Ref ] Gastrointestinal Gastrointestinal side effects have included nausea (30% to 35%), anorexia (19% to 23%), diarrhea (16% to 18%), vomiting (8% to 10%), constipation (6% to 8%), xerostomia (5% to 6%), abdominal pain (5% to 6%), dyspepsia (3% to 4%), flatulence (2% to 4%), and dry mouth. [ Ref ] Musculoskeletal Musculoskeletal side effects have included dystonia (19% to 22%), muscle cramps (17% to 18%), stiffness (2%), arthritis (1% to 2%), and hypertonia (1%). [ Ref ] Respiratory Respiratory side effects have included upper respiratory tract infection (5% to 7%), dyspnea (3%), and sinus congestion (1% to 2%). [ Ref ] Genitourinary Genitourinary side effects have included urine discoloration (2% to 7%), urinary tract infection (5%), and micturition disorder (1% to 2%). [ Ref ] Cardiovascular Cardiovascular side effects have included chest pain (1% to 3%), hypotension (2%), chest discomfort (1% to 2%), and orthostatic symptoms. [ Ref ] Dermatologic Dermatologic side effects have included dermal bleeding (1%), alopecia (1%), and increased sweating. At least one case of vitiligo has also been reported. [ Ref ] A case report of vitiligo has been reported in a 50-year-old man with Parkinson's disease one week after the start of therapy with tolcapone 300 mg per day. [ Ref ] Oncologic Oncologic side effects have included tumors of the skin (1%) and tumors of the uterus (1%). [ Ref ] Ocular Ocular side effects have included cataracts (1%) and inflamed eyes (1%). [ Ref ] Nervous system Nervous system side effects have included dyskinesia (42% to 51%), sleep disorder (24% to 25%), excessive dreaming (16% to 21%), somnolence (14% to 18%), orthostatic complaints (17%), dizziness (6% to 13%), confusion (10% to 11%), headache (10% to 11%), hallucination (8% to 10%), syncope (4% to 5%), hyperkinesia (2% to 3%), paresthesia (1% to 3%), hypokinesia (1% to 3%), loss of balance (2% to 3%), mental deficiency (1%), agitation (1%), hyperactivity (1%), and neuroleptic malignant-like syndrome. Akathisia, insomnia and sleep disturbances have also been reported. [ Ref ] The neuroleptic malignant-like syndrome was reported in an elderly patient. It was caused by abrupt withdrawal of tolcapone. [ Ref ] Other Other side effects have included fatigue (3% to 7%), falling (4% to 6%), increased sweating (4% to 7%), influenza (3% to 4%), neck pain (2%), burning (1% to 2%), irritability (1%), malaise (1%), panic reaction (1%), euphoria (1%), and fever (1%). [ Ref ] References 1. Olanow CW, Watkins PB "Tolcapone: An Efficacy and Safety Review (2007)." Clin Neuropharmacol 30 (2007): 287-294 2. "Product Information. Tasmar (tolcapone)." Roche Laboratories, Nutley, NJ. 3. Dingemanse J "Issues important for rational COMT inhibition." Neurology 55(11 Suppl 4) (2000): S24-7; discussion S28-32 4. Hanson MR, Galvez-Jimenez N "Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease." Semin Neurol 21 (2001): 15-22 5. Sabate M, Bosch A, Pedros C, Figueras A "Vitiligo associated with tolcapone and levodopa in a patient with Parkinson's disease." Ann Pharmacother 33 (1999): 1228-9 6. Iwuagwu CU, Riley D, Bonomo RA "Neuroleptic malignant-like syndrome in an elderly patient caused by abrupt withdrawal of tolcapone, a catechol-O-methyl transferase inhibitor." Am J Med 108 (2000): 517-8 Some side effects of tolcapone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA . Next Dosage Print this page More about tolcapone Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: dopaminergic antiparkinsonism agents Consumer resources Tolcapone Tolcapone (Advanced Reading) Other brands: Tasmar Professional resources Tolcapone (AHFS Monograph) Tolcapone (FDA) Tolcapone (Wolters Kluwer) Related treatment guides Parkinson's Disease Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Dopaminergic antiparkinsonism agents Related Drugs Parkinson's Disease Exelon , ropinirole , pramipexole , Sinemet , Requip , benztropine , carbidopa / levodopa , Mirapex , amantadine , rivastigmine , Azilect , Cogentin , selegiline , trihexyphenidyl , bromocriptine , entacapone , Neupro , Rytary , rasagiline , Stalevo , Artane , carbidopa / entacapone / levodopa , Comtan , belladonna , More... Tolcapone Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Tolcapone Images Tolcapone systemic 100 mg (EP 370) View larger images} } at the moment
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