instructions efavirenz, emtricitabine, and tenofovir (Oral route) ef-a-VYE-renz, em-trye-SYE-ta-been, ten-OF-oh-vir dye-soe-PROX-il FUE-ma-rate Oral route(Tablet) Efavirenz/emtricitabine/tenofovir disoproxil fumarate is not approved for the treatment of chronic hepatitis B virus (HBV) infection. Severe, acute exacerbations of hepatitis B have occurred in patients who have discontinued emtricitabine or tenofovir disoproxil fumarate. If patients are coinfected with HBV and HIV-1, monitor hepatic function closely for several months or more following the discontinuation of efavirenz/emtricitabine/tenofovir disoproxil fumarate, and consider starting anti-hepatitis B therapy if appropriate . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Atripla Available Dosage Forms: Tablet Therapeutic Class: Antiretroviral Agent Pharmacologic Class: Non-Nucleoside Reverse Transcriptase Inhibitor Slideshow Ladies A Moment: 10 Health Screenings That All Women Need Uses For efavirenz, emtricitabine, and tenofovir Efavirenz, emtricitabine, and tenofovir combination is used alone or with other anti-HIV medicines to treat human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). efavirenz, emtricitabine, and tenofovir does not cure or prevent HIV or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems that usually result from AIDS or HIV disease. It will not keep you from spreading HIV to other people. People who receive efavirenz, emtricitabine, and tenofovir may continue to have some of the problems usually related to AIDS or HIV disease. efavirenz, emtricitabine, and tenofovir is available only with your doctor's prescription. Before Using efavirenz, emtricitabine, and tenofovir In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For efavirenz, emtricitabine, and tenofovir, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to efavirenz, emtricitabine, and tenofovir or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of efavirenz, emtricitabine, and tenofovir combination in children 12 years of age and older with a body weight of at least 40 kg. However, safety and efficacy have not been established in children younger than 12 years of age. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of efavirenz, emtricitabine, and tenofovir combination in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving efavirenz, emtricitabine, and tenofovir combination. Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking efavirenz, emtricitabine, and tenofovir, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using efavirenz, emtricitabine, and tenofovir with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Carbamazepine Cisapride Dasabuvir Dronedarone Elbasvir Grazoprevir Mesoridazine Paritaprevir Pimozide Piperaquine Ritonavir Saquinavir Sparfloxacin St John's Wort Terfenadine Thioridazine Voriconazole Ziprasidone Using efavirenz, emtricitabine, and tenofovir with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alfuzosin Amiodarone Amitriptyline Amprenavir Anagrelide Apomorphine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Artemether Asenapine Astemizole Atazanavir Atovaquone Avanafil Axitinib Azithromycin Bedaquiline Bexarotene Boceprevir Bosutinib Bupropion Buserelin Chloroquine Chlorpromazine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Cobimetinib Crizotinib Cyclobenzaprine Cyclosporine Dabrafenib Daclatasvir Darunavir Dasatinib Deflazacort Degarelix Delamanid Desipramine Deslorelin Deutetrabenazine Dexamethasone Didanosine Disopyramide Dofetilide Dolasetron Dolutegravir Domperidone Donepezil Doxepin Doxorubicin Doxorubicin Hydrochloride Liposome Droperidol Ebastine Efavirenz Enzalutamide Eribulin Erythromycin Escitalopram Etravirine Famotidine Felbamate Fingolimod Flecainide Fluconazole Fluoxetine Formoterol Fosamprenavir Foscarnet Fosphenytoin Galantamine Gatifloxacin Gemifloxacin Ginkgo Biloba Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Idelalisib Ifosfamide Iloperidone Imipramine Itraconazole Ivabradine Ketoconazole Lapatinib Ledipasvir Leuprolide Levofloxacin Levonorgestrel Linagliptin Lumefantrine Maraviroc Mefloquine Methadone Methotrimeprazine Metronidazole Mifepristone Mizolastine Moricizine Moxifloxacin Nafarelin Naloxegol Nelfinavir Netupitant Nevirapine Nifedipine Nilotinib Norfloxacin Octreotide Ofloxacin Olanzapine Olaparib Ondansetron Orlistat Paliperidone Panobinostat Papaverine Paroxetine Pasireotide Pazopanib Pentamidine Perphenazine Pimavanserin Pipamperone Pitolisant Ponatinib Posaconazole Probucol Procainamide Prochlorperazine Proguanil Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Ranolazine Ribociclib Rifabutin Rifampin Rifapentine Rilpivirine Risperidone Sertindole Sevoflurane Simeprevir Sirolimus Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sonidegib Sorafenib Sotalol Sulpiride Sultopride Sunitinib Tacrolimus Tamoxifen Telavancin Telithromycin Tetrabenazine Tizanidine Tolterodine Tolvaptan Toremifene Trazodone Trimipramine Triptorelin Ulipristal Vandetanib Vardenafil Velpatasvir Vemurafenib Venetoclax Venlafaxine Vilanterol Vilazodone Vinflunine Vorinostat Warfarin Zotepine Zuclopenthixol Using efavirenz, emtricitabine, and tenofovir with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atorvastatin Caspofungin Darunavir Dienogest Diltiazem Estradiol Ethinyl Estradiol Ethynodiol Etonogestrel Indinavir Lopinavir Medroxyprogesterone Mestranol Norgestimate Ospemifene Pravastatin Ritonavir Sertraline Simvastatin Telaprevir Tipranavir Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other Medical Problems The presence of other medical problems may affect the use of efavirenz, emtricitabine, and tenofovir. Make sure you tell your doctor if you have any other medical problems, especially: Allergic reaction to efavirenz (eg, Stevens-Johnson syndrome, erythema multiforme, toxic skin eruptions), history of Should not be used in patients with this condition. Bone problems (eg, osteopenia), history of or Depression, history of or Fanconi syndrome (kidney disease), history of or Hepatitis B infection, history of or Heart rhythm problem (eg, QT prolongation) or Kidney failure, acute or Liver disease, mild or Seizures, history of Use with caution. May make these conditions worse. Kidney disease, moderate or severe or Liver disease, moderate or severe Use is not recommended in patients with these conditions. Proper Use of efavirenz, emtricitabine, and tenofovir Take efavirenz, emtricitabine, and tenofovir exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. efavirenz, emtricitabine, and tenofovir comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. Do not change the dose or stop using efavirenz, emtricitabine, and tenofovir without checking first with your doctor . When your supply of efavirenz, emtricitabine, and tenofovir is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of efavirenz, emtricitabine, and tenofovir. Take efavirenz, emtricitabine, and tenofovir on an empty stomach, at the same time each day, preferably at bedtime. Keep taking efavirenz, emtricitabine, and tenofovir for the full time of treatment even if you begin to feel better. It is also important that you continue taking all of the medicines that your doctor has given you for HIV infection. Dosing The dose of efavirenz, emtricitabine, and tenofovir will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of efavirenz, emtricitabine, and tenofovir. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For treatment of HIV infection: Adults and children 12 years of age and older and weighs at least 40 kilograms (kg) One tablet once a day. Children younger than 12 years of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of efavirenz, emtricitabine, and tenofovir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep the bottle tightly closed. Keep the medicine in the original bottle that you were given at the pharmacy. Precautions While Using efavirenz, emtricitabine, and tenofovir Your doctor will want to check your or your child's progress at regular visits , especially during the first few weeks that you take efavirenz, emtricitabine, and tenofovir. Blood tests may be needed to check for any unwanted effects. Do not use efavirenz, emtricitabine, and tenofovir together with adefovir (Hepsera ) or voriconazole (Vfend ). The medicines in this combination tablet are also available as Complera , Descovy , Emtriva , Genvoya , Odefsey , Stribild , Sustiva , Truvada , Vemlidy , or Viread . Do not take the efavirenz, emtricitabine, and tenofovir combination with any of these medicines . Using efavirenz, emtricitabine, and tenofovir while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. You should not become pregnant while you are taking efavirenz, emtricitabine, and tenofovir and for 12 weeks after stopping it. Some birth control pills may not work as well while you are using efavirenz, emtricitabine, and tenofovir. Use birth control pills together with another form of birth control, such as condoms, a diaphragm, or contraceptive foam or jelly. If you think you have become pregnant while using the medicine, tell your doctor right away. Two rare but serious reactions to efavirenz, emtricitabine, and tenofovir are lactic acidosis (too much acid in the blood) and liver toxicity. These are more common if you or your child are female, very overweight (obese), or have been taking anti-HIV medicines for a long time. Call your doctor right away if you have abdominal or stomach discomfort, cramping, nausea, vomiting, diarrhea, or a decreased appetite, muscle cramping or pain, unusual tiredness or weakness, trouble breathing, or yellow skin or eyes. Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation. You might have mood or behavior changes with efavirenz, emtricitabine, and tenofovir, such as feeling sad or hopeless, or getting upset easily. You could feel nervous or hostile, or have decreased awareness or responsiveness. Some people become violent and want to hurt themselves or others. Call your doctor right away if you or your child have any strange feelings, thoughts, or behaviors. Some people who have used efavirenz, emtricitabine, and tenofovir developed serious skin problems. Call your doctor right away if you or your child notice a severe skin rash, blistering, peeling, or loosening of the skin, red skin lesions, sores or ulcers on the skin, or fever or chills while you or your child are using efavirenz, emtricitabine, and tenofovir. efavirenz, emtricitabine, and tenofovir may also increase your risk of developing fractures (broken bones). Ask your doctor about this if you have any concerns. efavirenz, emtricitabine, and tenofovir may increase the risk of kidney problems. To lower this risk, avoid other medicines that can be harmful to the kidneys such as aminoglycoside antibiotics, certain other antiviral medicines, and NSAID pain medicines. efavirenz, emtricitabine, and tenofovir does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contaminated blood. Make sure you understand and practice safe sex, even if your partner also has HIV. Avoid sharing needles with anyone. efavirenz, emtricitabine, and tenofovir may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Be careful to limit the amount of alcohol that you drink, since alcohol can also make you drowsy. Make sure you know how you react to efavirenz, emtricitabine, and tenofovir before you drive, use machines, or do anything else that could be dangerous if you are not alert . Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you or your child notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis. Autoimmune disorders (such as Graves' disease, polymyositis, and Guillain-Barré syndrome) may also occur. efavirenz, emtricitabine, and tenofovir may cause you to have excess body fat. Tell your doctor if you notice changes in your body shape, such as an increased amount of fat in the upper back and neck, or around the chest and stomach area. You might also lose fat from the legs, arms, and face. Make sure any doctor or dentist who treats you knows that you or your child are using efavirenz, emtricitabine, and tenofovir. efavirenz, emtricitabine, and tenofovir may affect the results of certain medical tests. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. efavirenz, emtricitabine, and tenofovir Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Abdominal or stomach pain or tenderness blistering, peeling, or loosening of the skin body aches or pain clay-colored stools cough dark urine ear congestion fever or chills headache itching loss of voice muscle aches nausea and vomiting severe skin rash sore throat swelling of the feet or lower legs tightness of the chest trouble concentrating yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea dizziness unusual tiredness or weakness Less common Abnormal dreams decreased appetite decreased awareness or responsiveness discouragement feeling sad or empty irritability loss of appetite loss of interest or pleasure mild rash mimicry of speech or movements mutism negativism pain or tenderness around the eyes and cheekbones peculiar postures or movements, mannerisms or grimacing severe sleepiness trouble sleeping unusual drowsiness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about efavirenz/emtricitabine/tenofovir Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 102 Reviews Add your own review/rating Drug class: antiviral combinations Consumer resources Efavirenz, emtricitabine, and tenofovir Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate Other brands: Atripla Professional resources Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate (Wolters Kluwer) Related treatment guides HIV Infection Nonoccupational Exposure Occupational Exposure} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antiviral combinations Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , More... Nonoccupational Exposure Truvada , Atripla , Viread , lamivudine , abacavir , tenofovir , Epzicom , Reyataz , More... Occupational Exposure Truvada , Atripla , Viread , Isentress , lamivudine , abacavir , tenofovir , Epzicom , More... Efavirenz / emtricitabine / tenofovir Rating 102 User Reviews 9.0 /10 102 User Reviews 9.0 Rate it! Help and Support Looking for answers? Ask a question or go join the efavirenz / emtricitabine / tenofovir support group to connect with others who have similar interests.} } the fact
to illustrate efavirenz, emtricitabine, and tenofovir (Oral route) many people
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