are expecting Tolcapone Dosage Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Applies to the following strength(s): 100 mg ; 200 mg The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist. Usual Adult Dose for: Parkinson's Disease Additional dosage information: Renal Dose Adjustments Liver Dose Adjustments Dose Adjustments Precautions Dialysis Other Comments Usual Adult Dose for Parkinson's Disease Initial : 100 mg orally three times daily, always taken together with the first dose of the day of levodopa/carbidopa. Renal Dose Adjustments CrCl less than 25 mL/min: not recommended Liver Dose Adjustments Clearance and volume of distribution of unbound tolcapone was reduced by almost 50% in patients with moderate cirrhotic liver disease (Child-Pugh Class B). This change may increase the average serum concentration of unbound drug by twofold. Dose Adjustments The dose may be increased to 200 mg three times daily only if the anticipated incremental benefit is justified. If the patient fails to show substantial clinical benefit within 3 weeks of start of tolcapone, tolcapone should be discontinued. If the daily of dose of levodopa exceed 600 mg or if patient had moderate or severe dyskinesia, a decrease in dose may be warranted. Precautions Safety and effectiveness have not been established in pediatric patients (less than 18 years of age). There is no identified potential use of tolcapone in pediatric patients. Dialysis Hemodialysis: tolcapone is highly protein bound, therefore no significant removal of the drug is expected. Other Comments Tolcapone may be taken with or without food. Next Professional Print this page Add to My Med List More about tolcapone Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: dopaminergic antiparkinsonism agents Consumer resources Tolcapone Tolcapone (Advanced Reading) Other brands: Tasmar Professional resources Tolcapone (AHFS Monograph) Tolcapone (FDA) Tolcapone (Wolters Kluwer) Related treatment guides Parkinson's Disease Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Dopaminergic antiparkinsonism agents Related Drugs Parkinson's Disease Exelon , ropinirole , pramipexole , Sinemet , Requip , benztropine , carbidopa / levodopa , Mirapex , amantadine , rivastigmine , Azilect , Cogentin , selegiline , trihexyphenidyl , bromocriptine , entacapone , Neupro , Rytary , rasagiline , Stalevo , Artane , carbidopa / entacapone / levodopa , Comtan , belladonna , More... Tolcapone Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Tolcapone Images Tolcapone systemic 100 mg (EP 370) View larger images advantage of
is known Tolcapone Dosage recently
EmoticonEmoticon