and you are going atovaquone (Oral route) a-TOE-va-kwone Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Mepron Available Dosage Forms: Tablet Suspension Therapeutic Class: Antiprotozoal Chemical Class: Ubiquinone Slideshow Drug Prices Gone Wild: 10 Old Drugs, 10 New Pricetags Uses For atovaquone Atovaquone is used to prevent and treat Pneumocystis jiroveci pneumonia (PCP) in adults and children 13 years of age and older who cannot tolerate other medicines, such as trimethoprim-sulfamethoxazole. PCP is a very serious type of pneumonia which occurs usually in patients with poor immune systems, (such as cancer, AIDS, and organ transplanted patients). atovaquone is available only with your doctor's prescription. Before Using atovaquone In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For atovaquone, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to atovaquone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of atovaquone in children younger than 13 years of age. Safety and efficacy have not been established. Geriatric Although appropriate studies on the relationship of age to the effects of atovaquone have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking atovaquone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using atovaquone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Efavirenz Rifabutin Rifampin Using atovaquone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Indinavir Tetracycline Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of atovaquone. Make sure you tell your doctor if you have any other medical problems, especially: Liver disease Use with caution. May make this condition worse. Stomach or bowel problems Atovaquone may not work properly in patients with these conditions. Proper Use of atovaquone Use atovaquone exactly as directed by your doctor . Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Take atovaquone with food so that it can work properly. If you are using the oral liquid : atovaquone is available in two forms: foil pouch and a bottle. If you are using the medicine in the foil pouch: Take the 5-mL medicine by placing the contents of one pouch directly into your mouth, or use a dosing spoon or cup. If you need a 10-mL dose, take the entire contents of two pouches. If you are using the medicine in the bottle: Shake the bottle gently before using atovaquone. Use a specially marked measuring spoon, oral syringe, or medicine cup to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid. Atovaquone tablets may be crushed if necessary to make it easier to swallow. Because atovaquone tablets and oral suspension do not produce the same amount of medicine in the blood, the tablets and the suspension cannot be switched and used in place of each other. To help clear up your infection completely, keep using your medicine for the full time of treatment , even if you begin to feel better after a few days. If you stop taking atovaquone too soon, your symptoms may return. Dosing The dose of atovaquone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of atovaquone. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For prevention of Pneumocystis jiroveci pneumonia (PCP): For oral dosage form (suspension): Adults and children 13 years of age and older 1500 milligrams (mg) or 10 milliliters (mL) once a day with food. Children younger than 13 years of age Use and dose must be determined by your doctor. For treatment of Pneumocystis carinii pneumonia (PCP): For oral dosage form (suspension): Adults and children 13 years of age and older 750 milligrams (mg) or 5 milliliters (mL) two times a day with food for 21 days. Children younger than 13 years of age Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults 750 milligrams (mg) taken with a meal three times a day for 21 days. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of atovaquone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using atovaquone It is very important that your doctor check your progress at regular visits to make sure that atovaquone is working properly. Blood tests may be needed to check for unwanted effects. If your symptoms do not improve within a few days, or if they become worse, check with your doctor. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. atovaquone Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Cough or hoarseness difficult or labored breathing fever or chills lower back or side pain painful or difficult urination tightness in the chest Incidence not known Black, tarry stools bleeding gums bloating blood in the urine or stools bluish-colored lips, fingernails, or palms constipation dark urine dizziness or lightheadedness fast heartbeat headache indigestion large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools loss of appetite nausea noisy breathing pains in the stomach, side, or abdomen, possibly radiating to the back pale skin pinpoint red spots on the skin rapid heart rate sore throat unusual bleeding or bruising unusual tiredness or weakness vomiting yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain diarrhea lack or loss of strength runny nose skin rash sneezing sore mouth or tongue stuffy nose sweating trouble sleeping white patches in the mouth, tongue, or throat Incidence not known Blistering, peeling, or loosening of the skin eye irritation or redness itching or skin rash joint or muscle pain red skin lesions, often with a purple center Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about atovaquone Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 3 Reviews Add your own review/rating Drug class: miscellaneous antibiotics Consumer resources Atovaquone Other brands: Mepron Professional resources Atovaquone (AHFS Monograph) Atovaquone Suspension (FDA) Atovaquone (Wolters Kluwer) Related treatment guides Babesiosis Malaria Pneumocystis Pneumonia Prophylaxis Pneumocystis Pneumonia Toxoplasmosis} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Amneal Pharmaceuticals LLC Drug Class Miscellaneous antibiotics Related Drugs Babesiosis azithromycin , Zithromax , clindamycin , Cleocin , Mepron , More... Pneumocystis Pneumonia clindamycin , Bactrim , sulfamethoxazole / trimethoprim , Bactrim DS , leucovorin , More... Toxoplasmosis azithromycin , Zithromax , clindamycin , Bactrim , sulfamethoxazole / trimethoprim , More... Malaria doxycycline , hydroxychloroquine , clindamycin , Plaquenil , Cleocin , More... 1 more conditions... Atovaquone Rating 3 User Reviews 5.5 /10 3 User Reviews 5.5 Rate it! Related Questions & Answers Atovaquone/proguanil & alcohol? Atovaquone/Proguanil - Does this medication need to be taken each time you travel or is it good for? Read more questions} } rewarding
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