maintaining Loratadine use while Breastfeeding Drugs containing Loratadine: Claritin, Claritin-D, Loratadine-D 24 Hour, Alavert, Loratadine-D 12 Hour, Wal-itin, Claritin-D 24 Hour, AllerClear D-24 Hour, Claritin 24 Hour Allergy, Loratadine Reditab, Show all 31 Allergy Relief Tablets, Claritin Reditabs, Clear-Atadine, Children's Claritin Allergy, Claritin-D 12 Hour, Claritin Hives Relief, Tavist ND, Leader Allergy Relief D-24, Alavert D-12 Hour Allergy and Sinus, Clear-Atadine-D, Allergy Relief D12, Allergy & Congestion Relief, ohm Allergy Relief, Bactimicina Allergy, Clear-Atadine Children's, Dimetapp Children's ND Non-Drowsy Allergy, Help I Have Allergies, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Children's Allergy Relief 24 Hour, Allergy Relief 24 Hour, Allergy Relief D 24 Hour Overview Side Effects Dosage Professional Tips More Interactions Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Compare Alternatives Pricing & Coupons Loratadine Levels and Effects while Breastfeeding Summary of Use during Lactation Because of its lack of sedation and low milk levels, maternal use of loratadine would not be expected to cause any adverse effects in breastfed infants. Loratadine might have a negative effect on lactation, especially in combination with a sympathomimetic agent such as pseudoephedrine. The British Society for Allergy and Clinical Immunology recommends loratadine at its lowest dose as a preferred choice if an antihistamine is required during breastfeeding.[1] Drug Levels After a single oral dose of 40 mg of loratadine in 6 women, average peak milk levels of 29.2 (range 20.4 to 39) mcg/L occurred at two hours after the dose. In addition, average desloratadine peak milk levels of 16 (range 9 to 29.6) mcg/L occurred at 5.3 hours after the dose. The total amount excreted in milk over 48 hours was 11.7 mcg of loratadine and its metabolite. However, the dose administered was four times greater than the usual dose of the drug, so a total dose of about 3 mcg would be expected with a 10 mg dose. The calculated average and maximum expected doses of loratadine plus desloratadine in milk were 0.46 and 1.1% and of the maternal weight-adjusted dose, respectively, after the 40 mg dose.[2] Effects in Breastfed Infants A survey of 51 mothers who took loratadine during breastfeeding between 1999 and 2001 was conducted by a teratogen information service. Most of the infants were over 2 months old and loratadine was generally taken for one week or less. Two mothers reported minor sedation in their infants, one at 3 days of age and one at 3 months of age. Both mothers were taking a dose of 10 mg daily. Weight gain and psychomotor development were similar to infants in a control group of breastfed infants unexposed to medications.[3] An extension of the study that compared the results of this study (plus one additional patient) to that of a control group of 88 mothers who took a drug known to be safe while breastfeeding. No differences in sedation or any other side effects (p=0.606) in the infant were found between mothers who took loratadine during breastfeeding and those of the control group.[4] Effects on Lactation and Breastmilk Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[5][6] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[5] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed. One mother out of 51 mothers who took loratadine while nursing reported that she had decreased milk production after taking loratadine 10 mg daily for less than one week at 4 months postpartum.[3] Alternate Drugs to Consider Desloratadine , Fexofenadine References 1. Powell RJ, Du Toit GL, Siddique N et al. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007;37:631-50. PMID: 17456211 2. Hilbert J, Radwanski E, Affine MB et al. Excretion of loratadine in human breast milk. J Clin Pharmacol. 1988;28:234-9. PMID: 2966185 3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731 4. Merlob P, Stahl B. Prospective follow-up of adverse reactions in breast-fed infants exposed to loratadine treatment (1999-2001). BELTIS Newsl. 2002;Number 10:43-51. 5. Merlob P. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal loratadine treatment (1999-2002). Unpublished manuscript. 6. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996 Loratadine Identification Substance Name Loratadine CAS Registry Number 79794-75-5 Drug Class Antihistamines Nonsedating Antihistamines Administrative Information LactMed Record Number 163 Last Revision Date 20131022 Disclaimer Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site. Print this page Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy. More about loratadine Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Español 53 Reviews Add your own review/rating Drug class: antihistamines Consumer resources Loratadine Loratadine Capsules and Tablets Loratadine Chewable Tablets Loratadine Orally Disintegrating Tablets Loratadine Liquid Other brands: Claritin , Alavert , Wal-itin , Claritin Reditabs , ... +6 more Professional resources Loratadine (AHFS Monograph) ... +3 more Related treatment guides Allergic Rhinitis Urticaria Allergic Reactions Drug Status Rx OTC Availability Rx and/or OTC B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Loratadine Rating 53 User Reviews 6.2 /10 53 User Reviews 6.2 Rate it! Drug Class Antihistamines gaining knowledge of
in moderation Loratadine use while Breastfeeding all people
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