it will Elliotts B Solution Generic Name: sodium chloride, sodium bicarbonate, anhydrous dextrose, magnesium sulfate, potassium chloride, calcium chloride and sodium phosphate Dosage Form: intrathecal injection Overview Side Effects Professional Reviews Q & A More Pricing & Coupons Elliotts B Solution Description Elliotts B Solution is a sterile, nonpyrogenic, isotonic solution containing no bacteriostatic preservatives. Elliotts B Solution is a diluent for intrathecal administration of methotrexate sodium and cytarabine. Each 10 mL of Elliotts B Solution contains: Sodium Chloride, USP 73 mg Sodium Bicarbonate, USP 19 mg Dextrose, USP 8 mg Magnesium Sulfate • 7H 2 O, USP 3 mg Potassium Chloride, USP 3 mg Calcium Chloride • 2H 2 O, USP 2 mg Sodium Phosphate, dibasic • 7H 2 O, USP 2 mg Water for Injection, USP qs 10 mL Concentration of Electrolytes: Sodium 149 mEq/liter Bicarbonate 22.6 mEq/liter Potassium 4.0 mEq/liter Chloride 132 mEq/liter Calcium 2.7 mEq/liter Sulfate 2.4 mEq/liter Magnesium 2.4 mEq/liter Phosphate 1.5 mEq/liter The formulae and molecular weights of the ingredients are: INGREDIENT MOLECULAR FORMULA MOLECULAR WEIGHT Sodium Chloride NaCl 58.44 Sodium Bicarbonate NaHCO 3 84.01 Dextrose C 6 H 12 O 6 180.16 Magnesium Sulfate • 7H 2 O Mg 2 SO 4 • 7H 2 O 246.48 Potassium Chloride KCl 74.55 Calcium Chloride • 2H 2 O CaCl 2 • 2H 2 O 147.01 Sodium Phosphate, dibasic • 7H 2 O Na 2 HPO 4 • 7H 2 O 268.07 The pH of Elliotts B Solution is 6.0-7.5, and the osmolarity is 288 mOsmol per liter (calculated). Slideshow Binge Eating Disorder: Beyond Overeating Elliotts B Solution - Clinical Pharmacology Elliotts B Solution provides a buffered salt solution for use as a diluent for the intrathecal administration of methotrexate sodium and cytarabine. It has been demonstrated that Elliotts B Solution is comparable to cere brospinal fluid in pH, electrolyte composition, glucose content, and osmolarity: Comparison of Electrolyte Composition, pH and Nonelectrolytic Constituents of Elliotts B Solution and CSF Solution Na + mEq/L K + mEq/L Ca ++ mEq/L Mg ++ mEq/L HCO 3 - mEq/L Cl - mEq/L pH Phosphorus mg/dL Glucose mg/dL Cerebrospinal Fluid 117-137 2.3-4.6 2.2 2.2 22.9 113-127 7.31 1.2-2.1 45-80 Elliotts B Solution 149 4.0 2.7 2.4 22.6 132 6.0-7.5 2.3 80 The approximate buffer capacity of Elliotts B Solution is 1.1 X 10 -2 equivalents when the challenge solution is 0.01 N HCl and 7.8 X 10 -3 equivalents when the challenge solution is 0.01 N NaOH. 1 Compatibility studies with methotrexate sodium and cytarabine indicate these drugs are physically compati ble with Elliotts B Solution. Indications and Usage for Elliotts B Solution Elliotts B Solution is indicated as a diluent for the intrathecal administration of methotrexate sodium and cytarabine for the prevention or treatment of meningeal leukemia or lymphocytic lymphoma. Contraindications None known. Warnings Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by per sonnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. The labeling for methotrexate sodium and cytarabine should be consulted. Precautions General Particular attention should be taken to assure the maintenance of sterile technique throughout the procedure. (See DOSAGE AND ADMINISTRATION .) Carcinogenesis, Mutagenesis, Impairment of Fertility No standard mutagenicity or carcinogenicity studies have been conducted with Elliotts B Solution. Usage in Pregnancy All components of Elliotts B Solution are normal body constituents. Animal reproduction studies have not been conducted with Elliotts B Solution. Adverse Reactions Adverse reactions may occur with any given intrathecal injection due to the chemotherapy or the technique of intrathecal administration. (See product labeling for methotrexate sodium and cytarabine.) Preservative-free methotrexate sodium and cytarabine should be used to minimize adverse reactions due to preservatives. If an adverse reaction does occur, discontinue the administration, evaluate the patient, institute appropriate therapeutic countermeasures and, if possible, save the remainder of the unused solution(s) for examination. Drug Abuse and Dependence There is no potential for drug abuse or drug dependence. Overdosage Elliotts B Solution is a diluent. In the event of a drug, fluid or solute overload following administration, evalu ate the patient's condition, and institute appropriate corrective treatment. (See product labeling for methotrexate sodium and cytarabine.) Elliotts B Solution Dosage and Administration See product labeling for methotrexate sodium and cytarabine. Elliotts B Solution is intended for intrathecal administration only. Elliotts B Solution does not contain antibac terial preservatives and introduction of contaminated solutions into the cerebrospinal fluid may have extremely serious consequences. Therefore, administration of intrathecal solutions should be accomplished as soon as possible after preparation. A sterile filter-needle should be used to withdraw the contents of the ampule. Intrathecal drug products should be inspected visually for particulate matter and discoloration prior to admin istration. Preparation and Administration Precautions Elliotts B Solution is a diluent for the cytotoxic anticancer agents, methotrexate sodium and cytarabine. Care should be exercised in the handling and preparation of infusion solutions with these products. (See product labeling for methotrexate sodium and cytarabine.) How is Elliotts B Solution Supplied NDC SIZE 55792-007-10 10 mL ampule Elliotts B Solution is available in single-use clear glass ampules, packaged 10 ampules per box. Store at controlled room temperature, 20º-25ºC (68º-77ºF) [See USP]. Preservative Free. Discard unused portion. Use only if solution is clear and ampule is intact. Distributed by: Lukare Medical, LLC Scotch Plains, NJ 07076 1-855-752-9317 www.elliottsbsolution.com REFERENCES: 1. Cradock JC, et al. Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytara bine and hydrocortisone sodium succinate. American Journal of Hospital Pharmacy (1978); 35:402. Rev. 10/2015 PACKAGING Ampule labeling: Box labeling: ELLIOTTS B sodium cation, sodium bicarbonate, anhydrous dextrose, magnesium sulfate, potassium chloride, calcium chloride, sodium phosphate injection Product Information Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:55792-007 Route of Administration INTRATHECAL DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength sodium chloride (sodium cation and chloride ion) sodium chloride 73 mg in 10 mL sodium bicarbonate (bicarbonate ion) sodium bicarbonate 19 mg in 10 mL anhydrous dextrose (anhydrous dextrose) anhydrous dextrose 8 mg in 10 mL magnesium sulfate (magnesium cation) magnesium sulfate 3 mg in 10 mL potassium chloride (potassium cation) potassium chloride 3 mg in 10 mL calcium chloride (calcium cation) calcium chloride 2 mg in 10 mL sodium phosphate (phosphate ion) sodium phosphate 2 mg in 10 mL Inactive Ingredients Ingredient Name Strength Water 10 mL in 10 mL Packaging # Item Code Package Description 1 NDC:55792-007-10 10 AMPULE in 1 BOX 1 NDC:55792-007-01 10 mL in 1 AMPULE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020577 06/04/2013 Labeler - Lukare Medical, LLC (062862393) Registrant - Lukare Medical, LLC (062862393) Revised: 12/2015 Lukare Medical, LLC Next User Reviews Print this page Add to My Med List More about lvp solution Side Effects Support Group Pricing & Coupons 0 Reviews Add your own review/rating Drug class: intravenous nutritional products Consumer resources Icodextrin Intravenous (IV) Fluids Icodextrin Intraperitoneal (Advanced Reading) Professional resources Dextrose and Sodium Chloride Injection (FDA) Dextrose in Lactated Ringer's (FDA) Dextrose in Ringer's (FDA) Ringers (FDA) Other brands: Normosol-R , Plasma-Lyte 148 , Extraneal , Delflex , ... +2 more Related treatment guides Dehydration Peritoneal dialysis} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Manufacturer Baxter International Inc. Drug Class Intravenous nutritional products Related Drugs intravenous nutritional products cysteine , Novamine , Intralipid , fat emulsion Dehydration Normosol-R , Plasma-Lyte 148 , Isolyte S , More... Lvp solution Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first!} } detect
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