find out Daklinza Dosage Generic name: DACLATASVIR DIHYDROCHLORIDE 90mg Dosage form: tablet Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist. Testing Prior to the Initiation of Therapy Testing for HBV infection: Test all patients for evidence of current or prior HBV infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) before initiating HCV treatment with DAKLINZA [ see Warnings and Precautions (5.1) ]. NS5A Resistance Testing in HCV Genotype 1a-Infected Patients with Cirrhosis: Consider screening for the presence of NS5A polymorphisms at amino acid positions M28, Q30, L31, and Y93 in patients with cirrhosis who are infected with HCV genotype 1a prior to the initiation of treatment with DAKLINZA and sofosbuvir with or without ribavirin [ see Microbiology (12.4), Table 11 ]. Recommended Dosage The recommended dosage of DAKLINZA is 60 mg, taken orally, once daily, with or without food [ see Clinical Pharmacology (12.3) ]. Table 1 provides the recommended DAKLINZA-containing treatment regimens and duration based on HCV genotype and patient population. The optimal duration of DAKLINZA and sofosbuvir with or without ribavirin has not been established for HCV genotype 3 patients with cirrhosis or for HCV genotype 1 patients with Child-Pugh C cirrhosis [ see Clinical Studies (14.2 , 14.4) ]. For patients with HCV/HIV-1 coinfection, follow the dosage recommendations in Table 1 [ see Clinical Studies (14) ]. Refer to Drug Interactions (7) for dosage recommendations for concomitant HIV-1 antiviral drugs. For specific dosage recommendations for sofosbuvir, refer to the prescribing information. For HCV genotype 1 or 3 patients with Child-Pugh B or C cirrhosis or post-transplantation patients, the starting dose of ribavirin is 600 mg once daily, increasing up to 1000 mg daily as tolerated. The starting dose and on-treatment dose of ribavirin can be decreased based on hemoglobin and creatinine clearance. For HCV genotype 3 patients with compensated cirrhosis (Child-Pugh A), the recommended dosing of ribavirin is based on weight (1000 mg for patients weighing less than 75 kg and 1200 mg for those weighing at least 75 kg administered orally in two divided doses with food). Table 1: Recommended Treatment Regimen and Duration for DAKLINZA in Patients with Genotype 1 or 3 HCV Patient Population Treatment and Duration Genotype 1 Without cirrhosis DAKLINZA + sofosbuvir for 12 weeks Compensated (Child-Pugh A) cirrhosis Decompensated (Child-Pugh B or C) cirrhosis DAKLINZA + sofosbuvir + ribavirin for 12 weeks Post-transplant Genotype 3 Without cirrhosis DAKLINZA + sofosbuvir for 12 weeks Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis DAKLINZA + sofosbuvir + ribavirin for 12 weeks Post-transplant Dosage Modification Due to Drug Interactions Refer to the drug interactions and contraindications sections for other drugs before coadministration with DAKLINZA. Table 2: Recommended DAKLINZA Dosage Modification with CYP3A Inhibitors and Inducers Concomitant Drugs DAKLINZA Dosage Strong CYP3A inhibitors and certain HIV antiviral agents [ see Drug Interactions (7.3) ] 30 mg once daily Moderate CYP3A inducers and nevirapine [ see Drug Interactions (7.3) ] 90 mg once daily Strong CYP3A inducers [ see Contraindications (4) ] Contraindicated Dosage reduction of DAKLINZA for adverse reactions is not recommended. Discontinuation of Therapy If sofosbuvir is permanently discontinued in a patient receiving DAKLINZA with sofosbuvir, then DAKLINZA should also be discontinued. Next Professional Print this page Add to My Med List More about Daklinza (daclatasvir) Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 10 Reviews Add your own review/rating Drug class: NS5A inhibitors Consumer resources Daklinza Daklinza (Advanced Reading) Professional resources Daklinza (AHFS Monograph) Daklinza (FDA) Related treatment guides Hepatitis C Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Bristol-Myers Squibb Company Drug Class NS5A inhibitors Related Drugs Hepatitis C Harvoni , Epclusa , ribavirin , Zepatier , Mavyret , Sovaldi , sofosbuvir , ledipasvir / sofosbuvir , Vosevi , Viekira Pak , daclatasvir , Pegasys , Intron A , Ribasphere , Olysio , sofosbuvir / velpatasvir , Rebetol , simeprevir , Moderiba , PegIntron , elbasvir / grazoprevir , glecaprevir / pibrentasvir , Victrelis , More... Daklinza Rating 10 User Reviews 9.8 /10 10 User Reviews 9.8 Rate it! Daklinza Images Daklinza 30 mg (BMS 213) View all images searching for what you offer
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