within your means darunavir Generic Name: darunavir (da ROON a veer) Brand Name: Prezista Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A What is darunavir? Darunavir is a protease (PRO-tee-ayz) inhibitor antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. Darunavir is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Darunavir is not a cure for HIV or AIDS. Darunavir may also be used for purposes not listed in this medication guide. Slideshow HIV: Debunking The Myths of HIV And AIDS What is the most important information I should know about darunavir? Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with darunavir, and some drugs should not be used together. Darunavir can cause serious liver problems. Call your doctor if you have upper stomach pain, loss of appetite, tiredness, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Stop taking this medicine and call your doctor right away if you have a severe skin reaction: fever, burning or redness in your eyes, mouth sores, or a skin rash that spreads and causes blistering and peeling. What should I discuss with my healthcare provider before taking darunavir? You should not take this medication if you are allergic to darunavir or ritonavir (Norvir, Kaletra), or if you have severe liver disease. Some medicines can cause unwanted or dangerous effects when used with darunavir. Your doctor may need to change your treatment plan if you use any of the following drugs: alfuzosin; cisapride; colchicine (in people with liver or kidney disease); dronedarone; elbasvir and grazoprevir; lovastatin or simvastatin; pimozide, lurasidone; ranolazine; rifampin; sildenafil (Revatio, for pulmonary arterial hypertension); St. John's wort; triazolam or oral midazolam; or ergot medicines--dihydroergotamine, ergotamine, methylergonovine. To make sure darunavir is safe for you, tell your doctor if you have: liver disease (especially hepatitis B or C); diabetes; a bleeding disorder such as hemophilia; or an allergy to sulfa drugs. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of darunavir on the baby. Darunavir can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking darunavir. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. Darunavir and ritonavir should not be given to a child younger than 3 years old, or a child who weighs less than 22 pounds. How should I take darunavir? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Darunavir must be taken together with another medication called ritonavir. Take the medicines together at the same time every day. Take darunavir tablets with a full glass (8 ounces) of water or milk. Swallow the darunavir tablet whole. Do not break or chew. Darunavir works best if you take it with food, at the same time each day. Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with the oral dosing syringe provided with this medicine. If you did not receive an oral syringe with your medication, ask your pharmacist for one. While using darunavir, you may need frequent blood tests. Use darunavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose of darunavir and ritonavir as soon as you remember and take your next dose at the regularly scheduled time. Do not take extra medicine to make up the missed dose. Always take darunavir and ritonavir together. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking darunavir? If you also take didanosine (Videx), take it 1 hour before or 2 hours after you take darunavir. Taking darunavir will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Darunavir side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medicine and call your doctor right away if you have a severe skin reaction: fever, burning or redness in your eyes, mouth sores, or a skin rash that spreads and causes blistering and peeling. Call your doctor at once if you have: the first sign of any skin rash, no matter how mild; severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate; liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss. Darunavir may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with darunavir. Tell your doctor if you have: signs of a new infection--fever, night sweats, swollen glands, diarrhea, weight loss; chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath; cold sores, sores on your genital or anal area; rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement; trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex. Common side effects may include: nausea, vomiting, diarrhea, stomach pain; headache; rash; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Darunavir dosing information Usual Adult Dose for HIV Infection: Therapy-naive Patients and Therapy-experienced Patients with No Darunavir Resistance Associated Substitutions: Darunavir 800 mg plus ritonavir 100 mg orally once a day with food Therapy-experienced Patients with At Least 1 Darunavir Resistance Associated Substitution (including V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, and L89V): Darunavir 600 mg plus ritonavir 100 mg orally twice a day with food Comments: -Genotypic testing is recommended for therapy-experienced patients; however, when genotypic testing is not possible, darunavir 600 mg plus ritonavir 100 mg twice a day is recommended. Use: In combination with ritonavir and other antiretroviral agents, for the treatment of HIV-1 infection Usual Pediatric Dose for HIV Infection: 3 to less than 18 years: Therapy-naive Patients and Therapy-experienced Patients with No Darunavir Resistance Associated Substitutions: Oral suspension: 10 to less than 15 kg: Darunavir 35 mg/kg plus ritonavir 7 mg/kg orally once a day with food -or- 10 to less than 11 kg: Darunavir 350 mg plus ritonavir 64 mg orally once a day with food 11 to less than 12 kg: Darunavir 385 mg plus ritonavir 64 mg orally once a day with food 12 to less than 13 kg: Darunavir 420 mg plus ritonavir 80 mg orally once a day with food 13 to less than 14 kg: Darunavir 455 mg plus ritonavir 80 mg orally once a day with food 14 to less than 15 kg: Darunavir 490 mg plus ritonavir 96 mg orally once a day with food Tablets and oral suspension: 15 to less than 30 kg: Darunavir 600 mg plus ritonavir 100 mg orally once a day with food 30 to less than 40 kg: Darunavir 675 mg plus ritonavir 100 mg orally once a day with food 40 kg or more: Darunavir 800 mg plus ritonavir 100 mg orally once a day with food Therapy-experienced Patients with At Least 1 Darunavir Resistance Associated Substitution (including V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, and L89V): Oral suspension: 10 to less than 15 kg: Darunavir 20 mg/kg plus ritonavir 3 mg/kg orally twice a day with food -or- 10 to less than 11 kg: Darunavir 200 mg plus ritonavir 32 mg orally twice a day with food 11 to less than 12 kg: Darunavir 220 mg plus ritonavir 32 mg orally twice a day with food 12 to less than 13 kg: Darunavir 240 mg plus ritonavir 40 mg orally twice a day with food 13 to less than 14 kg: Darunavir 260 mg plus ritonavir 40 mg orally twice a day with food 14 to less than 15 kg: Darunavir 280 mg plus ritonavir 48 mg orally twice a day with food Tablets and oral suspension: 15 to less than 30 kg: Darunavir 375 mg plus ritonavir 48 mg orally twice a day with food 30 to less than 40 kg: Darunavir 450 mg plus ritonavir 60 mg orally twice a day with food 40 kg or more: Darunavir 600 mg plus ritonavir 100 mg orally twice a day with food Comments: -Special vigilance recommended during dose selection, medication order transcription, dispensing information, and dosing instructions to reduce risk for medication errors, overdose, and underdose. -Dose should not exceed the recommended adult dose. Use: In combination with ritonavir and other antiretroviral agents, for the treatment of HIV-1 infection What other drugs will affect darunavir? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with darunavir, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about darunavir Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 5 Reviews Add your own review/rating Drug class: protease inhibitors Consumer resources Darunavir Tablets Darunavir Oral Suspension Darunavir (Advanced Reading) Other brands: Prezista Professional resources Darunavir (AHFS Monograph) Darunavir (Wolters Kluwer) Related treatment guides HIV Infection Where can I get more information? Your pharmacist can provide more information about darunavir. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 7.01. Date modified: December 03, 2017 Last reviewed: August 10, 2017} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Protease inhibitors Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , abacavir , tenofovir , Epzicom , Reyataz , ritonavir , Complera , emtricitabine , Kaletra , Intelence , Sustiva , Epivir , efavirenz , nevirapine , atazanavir , raltegravir , Selzentry , Lexiva , More... Darunavir Rating 5 User Reviews 8.3 /10 5 User Reviews 8.3 Rate it! Related Questions & Answers I am wondering about the safety of crushing certain drugs. the safety of those administering? Read more questions} } is important
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