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do you know elosulfase alfa Generic Name: elosulfase alfa (EE loe SUL face AL fa) Brand Name: Vimizim Overview Side Effects Dosage Professional Pregnancy More User Reviews Support Group Q & A What is elosulfase alfa? Elosulfase alfa is used to treat some of the symptoms of a genetic condition called mucopolysaccharidosis (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis) IV (4) type A, or MPS IV A, also called Morquio A syndrome. MPS IVA is a metabolic disorder in which the body lacks the enzyme needed to break down certain sugars and proteins. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities. Elosulfase alfa may improve walking and stair-climbing ability in people with this condition. However, this medication is not a cure for MPS IVA. Elosulfase alfa may also be used for purposes not listed in this medication guide. Slideshow Inherited Risk: The BRCA Gene Explained What is the most important information I should know about elosulfase alfa? Some side effects may occur during the elosulfase alfa infusion, or up to several days afterward. Tell your caregiver right away if you feel dizzy, itchy, nauseated, light-headed, or if you have chest pain, tightness in your throat, pale skin, blue lips, diarrhea, or vomiting. You may be more likely to have a reaction to elosulfase alfa if you have a breathing disorder, or if you are sick with a fever at the time of your infusion. Your breathing, blood pressure, and other vital signs will be watched closely during and after the infusion, so your caregivers can quickly treat any serious side effects that occur. What should I discuss with my healthcare provider before taking elosulfase alfa? You should not receive this medicine if you are allergic to elosulfase alfa. To make sure this medicine is safe for you, tell your doctor if you have: asthma or any other lung problems; sleep apnea (breathing stops during sleep); or any current illness, especially if you have a fever. Your name may need to be listed on a Morquio A Registry while you are using this medicine. The purpose of this registry is to track the progression of this disorder and the effects that elosulfase alfa has on long-term treatment of Morquio A syndrome. FDA pregnancy category C. It is not known whether elosulfase alfa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. It is not known whether elosulfase alfa passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. How should I take elosulfase alfa? Elosulfase alfa is injected into a vein through an IV. You will most likely receive this injection in a clinic or hospital setting. Elosulfase alfa must be given slowly through an IV infusion, and can take up to 4 hours or longer to complete. Elosulfase alfa is usually given once per week. Follow your doctor's instructions. If a child is using this medicine, tell your doctor if the child has any changes in weight. Elosulfase alfa doses are based on body weight. Your doctor may also prescribe other medications to help prevent an allergic reaction to elosulfase alfa. Take all of your medications as directed. Your doctor will need to check your progress while you are using elosulfase alfa. What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your elosulfase alfa injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while taking elosulfase alfa? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Elosulfase alfa side effects Some side effects may occur during the elosulfase alfa infusion, or up to several days afterward. Tell your caregiver right away if you feel dizzy, itchy, nauseated, light-headed, or if you have chest pain, tightness in your throat, pale skin, blue lips, diarrhea, or vomiting. Get emergency medical help if you have any of these signs of an allergic reaction: hives; cough, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat. It may still be possible for you to receive elosulfase alfa even after you have had a reaction to it. There are other medications that can be given to you before your elosulfase alfa infusion to help prevent symptoms of a reaction. Common side effects of elosulfase alfa may include: nausea, vomiting, stomach pain; headache; fever, chills; tired feeling. Even though it may not be a side effect of elosulfase alfa, increased pressure on the spinal cord is a complication of MPS IVA that may occur while you are using this medicine. Tell your doctor right away if you have any symptoms of spinal cord compression : back pain; loss of movement in any part of your body; or loss of bowel or bladder control. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Elosulfase alfa dosing information Usual Adult Dose for Mucopolysaccharidosis Type IV: 2 mg/kg via IV infusion once a week Comments: -Should be infused over 3.5 to 4.5 hours, depending on infusion volume -Pretreatment with antihistamines with or without antipyretics is recommended 30 to 60 minutes before starting the infusion. Use: For patients with mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) Usual Pediatric Dose for Mucopolysaccharidosis Type IV: 5 years or older: 2 mg/kg via IV infusion once a week Comments: -Should be infused over 3.5 to 4.5 hours, depending on infusion volume -Pretreatment with antihistamines with or without antipyretics is recommended 30 to 60 minutes before starting the infusion. Use: For patients with MPS IVA What other drugs will affect elosulfase alfa? Other drugs may interact with elosulfase alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about elosulfase alfa Side Effects During Pregnancy Dosage Information Support Group En EspaƱol 0 Reviews Add your own review/rating Drug class: lysosomal enzymes Consumer resources Elosulfase Alfa Elosulfase alfa Intravenous (Advanced Reading) Other brands: Vimizim Professional resources Elosulfase Alfa (AHFS Monograph) Elosulfase Alfa (Wolters Kluwer) Related treatment guides Mucopolysaccharidosis Type IV Where can I get more information? Your doctor or pharmacist can provide more information about elosulfase alfa. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01. Date modified: December 03, 2017 Last reviewed: March 12, 2014} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Lysosomal enzymes Related Drugs Mucopolysaccharidosis Type IV Vimizim , More... Elosulfase alfa Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? 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