many manmade dorzolamide and timolol (Ophthalmic route) dor-ZOLE-a-mide hye-droe-KLOR-ide, TIM-oh-lol MAL-ee-ate Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Cosopt Cosopt Ocumeter Cosopt Ocumeter Plus Cosopt PF Available Dosage Forms: Solution Therapeutic Class: Antiglaucoma, Beta-Adrenergic Blocker/Carbonic Anhydrase Inhibitor Combination Pharmacologic Class: Dorzolamide Slideshow Easy On The Eye - 8 Tips for Maintaining Good Eyesight Uses For dorzolamide and timolol Dorzolamide and timolol ophthalmic (eye) drops is used to treat increased pressure in the eye caused by open-angle glaucoma or a condition called hypertension of the eye. Both eye conditions are caused by high pressure in your eye and can lead to pain from pressure in your eye and then can eventually harm your vision. dorzolamide and timolol can help you keep your sight by reducing the pressure in your eye and stopping eye pain. dorzolamide and timolol is available only with your doctor's prescription. Before Using dorzolamide and timolol In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dorzolamide and timolol, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to dorzolamide and timolol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of dorzolamide and timolol eye drops in children 2 years of age and older. However, safety and efficacy have not been established in children younger than 2 years of age. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dorzolamide and timolol eye drops in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking dorzolamide and timolol, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using dorzolamide and timolol with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Clonidine Crizotinib Diltiazem Dronedarone Epinephrine Fenoldopam Fingolimod Indacaterol Lacosamide Memantine Oxymetazoline Rivastigmine Verapamil Using dorzolamide and timolol with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acarbose Aceclofenac Acemetacin Acetyldigoxin Albiglutide Alfuzosin Alogliptin Amiodarone Amtolmetin Guacil Arbutamine Aspirin Bromfenac Bufexamac Bunazosin Canagliflozin Celecoxib Chlorpropamide Choline Salicylate Cimetidine Clonixin Dapagliflozin Deslanoside Dexibuprofen Dexketoprofen Diclofenac Diflunisal Digitoxin Digoxin Dipyrone Doxazosin Droxicam Dulaglutide Empagliflozin Etodolac Etofenamate Etoricoxib Exenatide Felbinac Fenoprofen Fepradinol Feprazone Floctafenine Flufenamic Acid Flurbiprofen Glimepiride Glipizide Glyburide Ibuprofen Indomethacin Insulin Aspart, Recombinant Insulin Degludec Insulin Detemir Insulin Glargine, Recombinant Insulin Glulisine Insulin Human Inhaled Insulin Human Isophane (NPH) Insulin Human Regular Insulin Lispro, Recombinant Ketoprofen Ketorolac Linagliptin Liraglutide Lixisenatide Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Metformin Methyldopa Metildigoxin Mibefradil Miglitol Morniflumate Moxisylyte Nabumetone Naproxen Nateglinide Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Oxaprozin Oxyphenbutazone Parecoxib Phenoxybenzamine Phentolamine Phenylbutazone Piketoprofen Pioglitazone Piroxicam Pramlintide Pranoprofen Prazosin Proglumetacin Propyphenazone Proquazone Repaglinide Rofecoxib Rosiglitazone Salicylic Acid Salsalate Saxagliptin Sitagliptin Sodium Salicylate St John's Wort Sulindac Tamsulosin Tenoxicam Terazosin Tiaprofenic Acid Tolazamide Tolbutamide Tolfenamic Acid Tolmetin Trimazosin Urapidil Valdecoxib Vildagliptin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of dorzolamide and timolol. Make sure you tell your doctor if you have any other medical problems, especially: Acute angle-closure glaucoma Use of dorzolamide and timolol eye drops in these patients have not been studied. This condition may need other medicine or treatment besides dorzolamide. Allergy, history of or Sulfonamide allergy (antibiotic or stomach medicines, e.g., sulfamethoxazole, sulfasalazine, sulfisoxazole, Azulfidine , Bactrim , or Septra ) Severity and duration of allergic reactions to other substances may be increased. Asthma, or history of or Bradycardia (unusually slow heartbeat) or Cardiogenic shock (shock caused by heart attack) or Chronic obstructive pulmonary disease (COPD), severe or Heart block or Heart failure Should not be used in patients with these conditions. Bacterial eye infection (e.g., keratitis) or Cornea (part of the eye) problems, history of or Eye surgery, recent Use with caution. May make these conditions worse. Diabetes or Hyperthyroidism (overactive thyroid) or Hypoglycemia (low blood sugar) May cover up some of the signs and symptoms of these disease, such as a fast heartbeat. Kidney disease, severe or Liver disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Myasthenia gravis (severe muscle disease) May worsen symptoms of this condition, such as muscle weakness. Proper Use of dorzolamide and timolol Your eye doctor will tell you how much of dorzolamide and timolol to use and how often. Do not use more medicine or use it more often than your doctor tells you to. dorzolamide and timolol comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. Use only the brand of dorzolamide and timolol that your doctor prescribed . Do not replace preservative-containing (Cosopt ) with the product without preservative (Cosopt PF) . Cosopt PF eye drops is a sterile solution that does not contain any preservatives. Use the solution in the single-unit containers immediately after opening. Throw away any unused medicine after each use. If you normally wear soft contact lenses, remove them before you use Cosopt eye drops. Wait at least for 15 minutes before putting the contact lenses back in. If you are using Cosopt PF eye drops , you may not need to remove your contact lenses while using dorzolamide and timolol. To use the Cosopt eye drops : The bottle is only partially full to provide proper drop control. First, wash your hands with soap and water. Before using dorzolamide and timolol for the first time, make sure that the safety strip on the bottle is unbroken. Tear off the safety strip to break the seal and open the bottle by unscrewing the cap by turning as indicated by the arrows on the top of the cap. Do not pull the cap directly up and away from the bottle. Tilt your head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Invert the bottle, and press lightly the "finger push area" using your thumb or index finger. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye. If you think you did not get the drop of medicine into your eye properly, replace the cap on the bottle and tighten. Then, remove by turning the cap in the opposite direction as indicated by the arrows on the top of the cap and repeat the process with another drop. Replace the cap by turning until it is firmly touching the bottle. Do not overtighten or you may damage the bottle and cap. Immediately after using the eye drops, wash your hands to remove any medicine that may be on them. To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye drops. To use the Cosopt PF eye drops : dorzolamide and timolol is packaged in a foil pouch containing a strip of single-use containers. First, wash your hands with soap and water. Pull off one single-use container from the strip. Return the remaining strip of single-use container back in the pouch. Hold the single-use container upright. Twist off the tab to open the container. Tilt your head backwards or lie down, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Blot any excess solution from the skin around the eye with a tissue. Discard and unused portion from the single use container. If your doctor ordered two different eye drops to be used together, wait at least 5 or 10 minutes between the times you apply the medicines. This will help to keep the second medicine from washing out the first one. Dosing The dose of dorzolamide and timolol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dorzolamide and timolol. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For ophthalmic dosage form (eye drops): For glaucoma or hypertension of the eye: Adults Use one drop in the affected eye two times a day (morning and evening). Children 2 years of age or older Dose must be determined by your doctor. Children younger than 2 years of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of dorzolamide and timolol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep the Cosopt PF single-use containers in the original pouch to protect from light. Write down the date you open the foil pouch in the space provided in the pouch. Throw away any unused single-use containers 15 days after opening the pouch. Precautions While Using dorzolamide and timolol It is very important that your doctor check the progress of you or your child at regular visits to make sure that dorzolamide and timolol is working properly. Blood and urine tests may be needed to check for unwanted effects. If itching, redness, swelling, or other signs of eye or eyelid irritation occur, stop using dorzolamide and timolol and check with your doctor. These signs may mean that you or your child are allergic to dorzolamide and timolol. dorzolamide and timolol may cause heart failure in some patients. Check with your doctor right away if you or your child are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing. Serious allergic reactions may occur while using dorzolamide and timolol. Stop using dorzolamide and timolol and check with your doctor right away if you or your child have any of the following symptoms: black, tarry stools; blistering, peeling, or loosening of the skin; chills; dark urine; joint or muscle pain; rash; red skin lesions, often with a purple center; sores, ulcers, or white spots in the mouth or on the lips; unusual bleeding or bruising; unusual tiredness or weakness; or yellow eyes or skin. dorzolamide and timolol may cause changes in your blood sugar levels. Also, dorzolamide and timolol may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you or your child have these problems or if you notice a change in the results of your blood or urine sugar tests. Before you have any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using dorzolamide and timolol. You may need to stop using dorzolamide and timolol several days before having surgery or medical tests. It is very important that you check with your doctor if you get an injury or infection in your eye or if you are scheduled to have eye surgery. Your doctor will tell you whether to keep using the same container of eye drops or whether you should start using a fresh bottle of eye drops. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. dorzolamide and timolol Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Blurred vision burning or stinging of the eye (when medicine is applied) feeling of something in the eye itching of the eye redness of the eye and lining of the eyelid sensitivity of the eyes to light Less common Back, abdominal, or stomach pain change in vision coughing, shortness of breath, troubled breathing, tightness in the chest, or wheezing discharge from the eye dizziness eye or eyelid pain, swelling, discomfort, or irritation increased blood pressure increased frequency of urination or painful urination itching of the eyelid seeing flashes or sparks of light seeing floating spots before the eyes swelling of lining of the eyelid tiny bumps on lining of the eyelid Rare Blistering, peeling, or loosening of the skin blood in the urine blue lips, fingernails, or skin chest pain or discomfort chills cough diarrhea difficult or troubled breathing fainting headache or weakness, severe and sudden irregular, fast or slow, or shallow breathing itching joint or muscle pain lightheadedness mental depression nausea or vomiting pain, numbness, tingling, or burning feeling in the hands or feet red, irritated eyes red skin lesions, often with a purple center shortness of breath skin rash slow or irregular heartbeat sore throat sores, ulcers, or white spots in the mouth or on the lips sweating unusual tiredness or weakness Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Confusion muscle cramps or pain numbness, tingling, pain, or weakness in the hands or feet seizures trembling weakness and heaviness of the legs Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Bitter, sour, or unusual taste Less common Cold- or flu-like symptoms crusting or scales on eyelid dryness of the eyes indigestion or upset stomach sore throat stuffy or runny nose tearing of the eye Rare Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings depression dry mouth stuffy nose Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 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Next Side Effects Print this page Add to My Med List More about dorzolamide/timolol ophthalmic Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 6 Reviews Add your own review/rating Drug class: ophthalmic glaucoma agents Consumer resources Dorzolamide and timolol ophthalmic Dorzolamide/Timolol Eye Drops Dorzolamide/Timolol Preservative-Free Eye Drops Other brands: Cosopt , Cosopt PF Professional resources Dorzolamide and Timolol Ophthalmic Solution (FDA) Dorzolamide and Timolol (Wolters Kluwer) Related treatment guides Glaucoma, Open Angle Intraocular Hypertension} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA WADA Class Anti-Doping Classification Manufacturer Akorn, Inc. Drug Class Ophthalmic glaucoma agents Related Drugs Intraocular Hypertension timolol ophthalmic , Lumigan , latanoprost ophthalmic , Travatan , brimonidine ophthalmic , Xalatan , Combigan , Alphagan , dorzolamide ophthalmic , pilocarpine ophthalmic , Cosopt , Azopt , More... Glaucoma, Open Angle timolol ophthalmic , Lumigan , latanoprost ophthalmic , Travatan , brimonidine ophthalmic , Xalatan , epinephrine ophthalmic , Alphagan , dorzolamide ophthalmic , pilocarpine ophthalmic , Cosopt , Azopt , More... Dorzolamide / timolol ophthalmic Rating 6 User Reviews 6.0 /10 6 User Reviews 6.0 Rate it! Help and Support Looking for answers? Ask a question or go join the dorzolamide / timolol support group to connect with others who have similar interests.} } optimum
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