trudging away [30:60 years, hypertension, diabetes), estimate the glomerular filtration rate (GFR) through laboratory testing ( 5.1 ). For patients at highest risk for NSF, do not exceed the recommended Dotarem dose and allow a sufficient period of time for elimination of the drug from the body prior to any re-administration [see Warnings and Precautions ( 5.1 )] . Indications and Usage for Dotarem Dotarem is a gadolinium-based contrast agent indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (including term neonates) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity. Slideshow Treatment of Opioid-Induced Constipation: The Hard Facts Dotarem Dosage and Administration Dosing Guidelines For adult and pediatric patients (including term neonates), the recommended dose of Dotarem is 0.2 mL/kg (0.1 mmol/kg) body weight administered as an intravenous bolus injection, manually or by power injector, at a flow rate of approximately 2 mL/second for adults and 1 - 2 mL/second for pediatric patients. Table 1 provides weight-adjusted dose volumes. Table 1: Volumes of Dotarem Injection by Body Weight Body Weight Volume Pounds (lb) Kilograms (kg) Milliliters (mL) 5.5 2.5 0.5 11 5 1 22 10 2 44 20 4 66 30 6 88 40 8 110 50 10 132 60 12 154 70 14 176 80 16 198 90 18 220 100 20 242 110 22 264 120 24 286 130 26 308 140 28 330 150 30 To ensure complete injection of Dotarem the injection may be followed by normal saline flush. Contrast MRI can begin immediately following Dotarem injection. Drug Handling Visually inspect Dotarem for particulate matter prior to administration. Do not use the solution if particulate matter is present or if the container appears damaged. Dotarem should be a clear, colorless to yellow solution. Do not mix with other drugs or parenteral nutrition. Discard any unused portions of the drug. When Dotarem is to be injected using plastic disposable syringes, the contrast medium should be drawn into the syringe and used immediately. Pharmacy Bulk Package Preparation: Do not use the Pharmacy Bulk Package for direct intravenous infusion. Perform the transfer of Dotarem from the Pharmacy Bulk Package in an aseptic work area, such as laminar flow hood and using aseptic technique and suitable transfer device. Penetrate the closure only one time. Once the container closure is punctured, do not remove the Pharmacy Bulk Package from the aseptic work area. The Pharmacy Bulk Package is used as a multiple dose container with an appropriate transfer device for filling empty sterile syringes. Use each individual dose of Dotarem promptly following withdrawal from the Pharmacy Bulk Package. Use the contents of the Pharmacy Bulk Package within 24 hours after initial puncture. Dosage Forms and Strengths Dotarem 0.5 mmol/mL is a sterile, clear, colorless to yellow, aqueous solution for intravenous injection containing 376.9 mg/mL gadoterate meglumine. Dotarem Pharmacy Bulk Package is available in vials. Contraindications History of clinically important hypersensitivity reactions to Dotarem [see Warnings and Precautions ( 5.2 )]. Warnings and Precautions Nephrogenic Systemic Fibrosis Gadolinium-based contrast agents (GBCAs) increase the risk for nephrogenic systemic fibrosis (NSF) among patients with impaired elimination of the drugs. Avoid use of GBCAs among these patients unless the diagnostic information is essential and not available with non-contrast MRI or other modalities. The GBCA-associated NSF risk appears highest for patients with chronic, severe kidney disease (GFR] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Magnetic resonance imaging contrast media Related Drugs magnetic resonance imaging contrast media Magnevist , gadobutrol , gadobenate dimeglumine , OptiMARK , Multihance , Gadavist CNS Magnetic Resonance Imaging Magnevist , gadobutrol , gadobenate dimeglumine , Gadavist , Multihance , Prohance , Omniscan , gadoterate meglumine , gadodiamide , gadoteridol , More... Dotarem Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! novices
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