any one dornase alfa (Inhalation route) DOR-nase AL-fa Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Pulmozyme Available Dosage Forms: Solution Therapeutic Class: Mucolytic Pharmacologic Class: Mucolytic Enzyme Slideshow It's In The Genes - Record Your Family Health History Uses For dornase alfa Dornase alfa inhalation solution is used together with other medicines (eg, antibiotics, bronchodilators, and steroids) to control symptoms of cystic fibrosis. Cystic fibrosis is a condition in which a thick mucus is formed in the lungs and breathing passages. The mucus blocks the airways and increases the chance of lung infections. The infections then cause the mucus to become even thicker, making it more difficult to breathe. Dornase alfa will not cure cystic fibrosis. However, when it is used every day, it helps make breathing easier and reduces the number of serious lung infections that require treatment with antibiotics. dornase alfa is available only with your doctor's prescription. Before Using dornase alfa In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dornase alfa, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to dornase alfa or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Pulmozyme in children 5 years of age and older. Geriatric Although appropriate studies on the relationship of age to the effects of Pulmozyme have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of dornase alfa. Make sure you tell your doctor if you have any other medical problems, especially: Allergy to Chinese hamster ovary cell products Should not be used in patients with this condition. Proper Use of dornase alfa dornase alfa usually comes with patient instructions. Read them carefully before using the medicine. If you do not understand the directions or you are not sure how to use the nebulizer, ask your doctor to show you how to use it. Use dornase alfa only as directed by your doctor . Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Also, do not stop using dornase alfa without telling your doctor. To do so may cause your lung condition to become worse. To use: Dornase alfa inhalation solution comes in small plastic containers called ampules. Each ampule contains one full dose of dornase alfa. Do not use an ampule that has already been opened. Dornase alfa should be used with the eRapid nebulizer system or a jet nebulizer that is connected to an air compressor. An air compressor is used with a nebulizer to turn the medicine into a fine spray. You will breathe in the spray through your mouth. Use the mouthpiece of the nebulizer to breathe in Pulmozyme . Do not use a face mask with the nebulizer because less medicine will get into your lungs. Patients who are unable to breathe in or breathe out by mouth may use the PARI BABY nebulizer with the supplied face mask. Make sure you understand exactly how to use dornase alfa in the nebulizer. Do not use a cloudy or discolored inhalation solution. You will need to use the nebulizer for about 10 to 15 minutes, or until the medicine in the nebulizer cup is gone. Follow the manufacturer's directions for care and cleaning of the nebulizer and compressor. In order to receive the full effects of dornase alfa, you must use it every day as ordered by your doctor . If possible, dornase alfa should be used at about the same time each day. You may notice some improvement in your condition within the first week of treatment. However, some patients may not feel the full effects of dornase alfa for weeks or months. If you are taking any other medicines for cystic fibrosis, keep taking them as you did before you started using dornase alfa, unless otherwise directed by your doctor. However, do not put any other inhaled medicine in the nebulizer at the same time that you use dornase alfa. Other inhaled medicines may be used in a clean nebulizer before or after your treatment with dornase alfa. Dosing The dose of dornase alfa will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dornase alfa. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For inhalation dosage form (solution): For cystic fibrosis: Adults and children 5 years of age and older 2.5 milligrams (mg) (one ampule) once a day in the nebulizer. Children 3 months to 4 years of age Dose must be determined by your doctor. The dose is usually 2.5 mg (one ampule) once a day in the nebulizer. Children younger than 3 months of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of dornase alfa, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in the refrigerator in the foil pouches. However, keep the medicine from freezing. Do not leave dornase alfa out of the refrigerator for longer than 24 hours. If an ampule of medicine is left out for longer than this, it should be thrown away and a new ampule should be used. Precautions While Using dornase alfa It is very important that your doctor check the progress of you or your child at regular visits . This is to make sure that the medicine is working properly and to check for unwanted effects. If your or your child's condition becomes worse while you are using dornase alfa, check with your doctor right away. If any of your medicines do not seem to be working as well as usual, call your doctor right away. Do not change your doses or stop using your medicines without asking your doctor. dornase alfa Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Body aches or pain chest pain congestion cough dryness or soreness of the throat fever hoarseness runny nose tender, swollen glands in the neck trouble breathing trouble swallowing voice changes Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach belching heartburn indigestion rash sneezing stomach discomfort, upset, or pain stuffy nose Less common Burning, dry, or itching eyes discharge or excessive tearing redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about dornase alfa Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 1 Review Add your own review/rating Drug class: miscellaneous respiratory agents Consumer resources Dornase alfa inhalation Dornase Alfa Other brands: Pulmozyme Professional resources Dornase Alfa (AHFS Monograph) Dornase Alfa (Wolters Kluwer) Related treatment guides Cystic Fibrosis} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Miscellaneous respiratory agents Related Drugs Cystic Fibrosis azithromycin , Zithromax , vitamin e , Creon , gentamicin , tobramycin , Zenpep , pancrelipase , amikacin , aztreonam , Garamycin , Azactam , Pulmozyme , Pancreaze , Orkambi , Amikin , pancreatin , Tobi , Cayston , dornase alfa , Alpha E , Kalydeco , More... 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