grow to be dornase alfa (inhalation) Generic Name: dornase alfa (inhalation) (DOOR nase AL fa) Brand Name: Pulmozyme Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A What is dornase alfa? Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis. Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections. Dornase alfa may also be used for purposes other than those listed in this medication guide. Slideshow Cystic Fibrosis: Living With The Octopus Inside Your Chest What is the most important information I should know about dornase alfa? Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications. Ampules of dornase alfa do not contain a preservative. Once opened, the entire contents of the ampule must be used or discarded. Dornase alfa must be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch. Dornase alfa should be kept refrigerated during transport. Combined lengths of exposure of the medication to room temperature should not exceed 24 hours. What should I discuss with my healthcare provider before using dornase alfa? Do not use dornase alfa if you have had an allergic reaction to it or to other Chinese Hamster Ovary cell products. Before using dornase alfa, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medicines. You may require a dosage adjustment or special monitoring during your treatment. Dornase alfa is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether dornase alfa passes into breast milk. Do not use dornase alfa without first talking to your doctor if you are breast-feeding a baby. How should I use dornase alfa? Use dornase alfa exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Dornase alfa is administered by inhalation using a recommended nebulizer. Your doctor or other healthcare provider will give you detailed instructions on the use and maintenance of the nebulizer. Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications. If you are also taking other respiratory medications, use them in the order directed by your doctor (e.g., a bronchodilator, followed by chest physiotherapy, then dornase alfa, etc.) Do not dilute or mix dornase alfa with other agents in the nebulizer at the same time. Ampules of dornase alfa do not contain a preservative. It is intended for one-time use only. Once opened, the entire contents of the ampule must be used or discarded. Do not use any dornase alfa solution that is cloudy or discolored. Throw away any unused dornase alfa on the expiration date stamped on the ampule. Dornase alfa should be used on a regular basis to get the most benefit. Dornase alfa must be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch. Dornase alfa should be kept refrigerated during transport. Combined lengths of exposure of the medication to room temperature should not exceed 24 hours. What happens if I miss a dose? Use the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and use only the next regularly scheduled dose as directed. Do not use a double dose. What happens if I overdose? An overdose of dornase alfa is unlikely to threaten life. If an overdose is suspected, contact your doctor, a hospital emergency room, or a poison control center. Symptoms of a dornase alfa overdose are not known. What should I avoid while using dornase alfa? Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications. Dornase alfa side effects If you experience any of the following serious side effects while taking dornase alfa, seek emergency medical attention or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); increased difficulty breathing; chest pain; or fever. Less serious side effects may be more likely to occur with the use of dornase alfa. Talk to your doctor if you experience any of the following side effects: voice alteration; sore throat; rash; laryngitis; eye redness, irritation, or inflammation; or nasal stuffiness or discharge. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Dornase alfa dosing information Usual Adult Dose for Cystic Fibrosis: 2.5 mg (1 single-use ampule) inhaled orally once daily using a recommended nebulizer/compressor system Comment: -Some patients may benefit from twice daily administration. Use: -Coadministration with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function -To reduce the risk of respiratory tract infections requiring parenteral antibiotics in CF patients with a Force Vital Capacity (FVC) of 40% or more Usual Pediatric Dose for Cystic Fibrosis: 5 years or older: 2.5 mg (1 single-use ampule) inhaled orally once daily using a recommended nebulizer/compressor system Comment: -Some patients may benefit from twice daily administration. Uses: -Coadministration with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function -To reduce the risk of respiratory tract infections requiring parenteral antibiotics in CF patients with a Force Vital Capacity (FVC) of 40% or more What other drugs will affect dornase alfa? There are no known interactions between dornase alfa and other medicines. Talk to your doctor or pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with dornase alfa. Next Side Effects Print this page Add to My Med List More about dornase alfa Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 1 Review Add your own review/rating Drug class: miscellaneous respiratory agents Consumer resources Dornase Alfa Dornase alfa Inhalation, oral/nebulization (Advanced Reading) Other brands: Pulmozyme Professional resources Dornase Alfa (AHFS Monograph) Dornase Alfa (Wolters Kluwer) Related treatment guides Cystic Fibrosis Where can I get more information? Your pharmacist has more information about dornase alfa written for health professionals that you may read. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 2.06. Date modified: December 03, 2017 Last reviewed: December 15, 2010} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Miscellaneous respiratory agents Related Drugs Cystic Fibrosis azithromycin , Zithromax , vitamin e , Creon , gentamicin , tobramycin , Zenpep , pancrelipase , amikacin , aztreonam , Garamycin , Pulmozyme , Azactam , Pancreaze , Orkambi , Amikin , pancreatin , Tobi , Cayston , Alpha E , Kalydeco , Pertzye , More... Dornase alfa Rating 1 User Review 10 /10 1 User Review 10 Rate it! Help and Support Looking for answers? Ask a question or go join the dornase alfa support group to connect with others who have similar interests.} } profits
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